Association of PON1 and PON2 Polymorphisms with PON1 Activity and Significant Coronary Stenosis in a Tunisian Population

PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways. We studied the distribution of PON1 and PON2 polymorphisms, including genotyping, lipid profile, and PON1 activity, and...

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Bibliographic Details
Published in:Biochemical genetics 2013-02, Vol.51 (1-2), p.76-91
Main Authors: Rejeb, Jihène, Omezzine, Asma, Rebhi, Lamia, Boumaiza, Imen, Mabrouk, Hajer, Rhif, Hamida, Rejeb, Nabila Ben, Nabli, Naoufel, Douki, Wahiba, Abdelaziz, Ahmed Ben, Boughzala, Essia, Bouslama, Ali
Format: Article
Language:English
Subjects:
Adult
Aged
Aryldialkylphosphatase - genetics
Base Sequence
Biochemistry
Biomedical and Life Sciences
Biomedicine
Cardiovascular diseases
Coronary Stenosis - enzymology
Coronary Stenosis - genetics
diabetes
DNA Primers
enzymes
Female
genes
Genotypes
genotyping
haplotypes
Human Genetics
Humans
Male
Medical Microbiology
Metabolic disorders
metabolic syndrome
metabolism
Middle Aged
myocardial ischemia
patients
risk
Tunisia
Zoology
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Summary:PON1 and PON2 have attracted considerable attention as candidate genes for coronary heart disease because their enzymes function as key factors in lipoprotein catabolism pathways. We studied the distribution of PON1 and PON2 polymorphisms, including genotyping, lipid profile, and PON1 activity, and their association with PON1 activity and significant coronary stenosis (SCS) in a Tunisian population. PON1 activity was lower in patients with SCS than in controls. It increased with the R allele (QQ 
ISSN:0006-2928
1573-4927
DOI:10.1007/s10528-012-9544-y