Comparison between stress myocardial perfusion SPECT recorded with cadmium-zinc-telluride and Anger cameras in various study protocols

Purpose The results of stress myocardial perfusion SPECT could be enhanced by new cadmium-zinc-telluride (CZT) cameras, although differences compared to the results with conventional Anger cameras remain poorly known for most study protocols. This study was aimed at comparing the results of CZT and...

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Published in:European journal of nuclear medicine and molecular imaging 2013-02, Vol.40 (3), p.331-340
Main Authors: Verger, Antoine, Djaballah, Wassila, Fourquet, Nicolas, Rouzet, François, Koehl, Grégoire, Imbert, Laetitia, Poussier, Sylvain, Fay, Renaud, Roch, Véronique, Le Guludec, Dominique, Karcher, Gilles, Marie, Pierre-Yves
Format: Article
Language:English
Subjects:
Cadmium
Cadmium zinc telluride
Cameras
Cardiology
Comparative studies
Female
Gamma Cameras
Heart
Heart - diagnostic imaging
Heart - physiopathology
Humans
Imaging
Male
Medicine
Medicine & Public Health
Middle Aged
Myocardial Perfusion Imaging - instrumentation
Nuclear Medicine
Obesity - diagnostic imaging
Obesity - physiopathology
Oncology
Original Article
Orthopedics
Radiology
Stress
Stress, Physiological
Tellurium
Tomography, Emission-Computed, Single-Photon - instrumentation
Zinc
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Summary:Purpose The results of stress myocardial perfusion SPECT could be enhanced by new cadmium-zinc-telluride (CZT) cameras, although differences compared to the results with conventional Anger cameras remain poorly known for most study protocols. This study was aimed at comparing the results of CZT and Anger SPECT according to various study protocols while taking into account the influence of obesity. Methods The study population, which was from three different institutions equipped with identical CZT cameras, comprised 276 patients referred for study using protocols involving 201 Tl ( n  = 120) or 99m Tc-sestamibi injected at low dose at stress ( 99m Tc-Low; stress/rest 1-day protocol; n  = 110) or at high dose at stress ( 99m Tc-High; rest/stress 1-day or 2-day protocol; n  = 46). Each Anger SPECT scan was followed by a high-speed CZT SPECT scan (2 to 4 min). Results Agreement rates between CZT and Anger SPECT were good irrespective of the study protocol (for abnormal SPECT, 201 Tl 92 %, 99m Tc-Low 86 %, 99m Tc-High 98 %), although quality scores were much higher for CZT SPECT with all study protocols. Overall correlations were high for the extent of myocardial infarction ( r  = 0.80) and a little lower for ischaemic areas ( r  = 0.72), the latter being larger on Anger SPECT ( p  
ISSN:1619-7070
1619-7089
DOI:10.1007/s00259-012-2292-8