Meta-analysis demonstrates lack of association between the ACE gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome occurrence and severity

Published data on a possible association between the angiotensin-converting enzyme (ACE) gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome (OSAHS) occurrence and its severity risk are inconclusive. We performed a meta-analysis of case-control studies published in English or Chinese...

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Bibliographic Details
Published in:Genetics and molecular research 2013-01, Vol.12 (1), p.74-84
Main Authors: Feng, Y, Ri, J, Wan, H Y, Shi, G C, Li, Q Y, Fan, L
Format: Article
Language:English
Subjects:
ACE protein
Adult
Aged
Asian Continental Ancestry Group - genetics
Case-Control Studies
Child, Preschool
Data processing
Ethnic groups
Female
Gene polymorphism
Genetic Predisposition to Disease
Humans
Male
Middle Aged
Peptidyl-dipeptidase A
Peptidyl-Dipeptidase A - genetics
Polymorphism, Genetic
Reviews
Sleep
Sleep Apnea, Obstructive - genetics
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Summary:Published data on a possible association between the angiotensin-converting enzyme (ACE) gene I/D polymorphism and obstructive sleep apnea-hypopnea syndrome (OSAHS) occurrence and its severity risk are inconclusive. We performed a meta-analysis of case-control studies published in English or Chinese. Thirteen studies, totaling 1361 cases and 1373 controls, were investigated for association of the ACE I/D polymorphism with OSAHS. We also made a study of ACE I/D with OSAHS severity risk, including 879 mild/moderate OSAHS patients and 357 severe OSAHS patients. A random-effects model was used, irrespective of between-study heterogeneity. Study quality was assessed in duplicate. Overall, the ACE I/D polymorphism was not significantly associated with an increase in OSAHS risk [odds ratio (OR) = 1.21; 95% confidence interval (95%CI) = 0.88-1.65; P = 0.24]. In subgroup analysis by ethnicity, comparison of alleles I with D demonstrated a 58% (nonsignificantly) increased risk for OSAHS in Chinese (OR = 1.58; 95%CI = 0.92-2.70; P = 0.09). We also found that there was no significant association between ACE I/D and OSAHS severity risk. No publication biases were observed. This meta-analysis suggests that there is no significantly increased risk for OSAHS occurrence or severity associated with the ACE I/D polymorphism.
ISSN:1676-5680
1676-5680
DOI:10.4238/2013.January.22.6