NSCLC subtype prediction using cytologic fluid specimens from needle aspiration biopsies

This study evaluated the diagnostic usefulness of tumor marker concentrations in cytologic fluids (CF) for subtyping non-small cell lung cancer (NSCLC) and assessed the relationship between fluorine-18-fluorodeoxyglucose ((18)F-FDG) uptake with serum and CF tumor marker levels. This prospective stud...

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Bibliographic Details
Published in:American journal of clinical pathology 2013-03, Vol.139 (3), p.309-316
Main Authors: Cho, Arthur, Hur, Jin, Hong, Yoo Jin, Lee, Hye-Jeong, Kim, Young Jin, Kim, Hee Yeong, Lee, Ji Won, Shim, Hyo Sup, Choi, Byoung Wook
Format: Article
Language:English
Subjects:
Aged
Antigens, Neoplasm - analysis
Area Under Curve
Biomarkers, Tumor - analysis
Biopsy, Needle
Body Fluids - chemistry
Carcinoembryonic Antigen - analysis
Carcinoma, Non-Small-Cell Lung - diagnosis
Carcinoma, Non-Small-Cell Lung - diagnostic imaging
Carcinoma, Non-Small-Cell Lung - surgery
Cytodiagnosis
Female
Fluorodeoxyglucose F18
Humans
Keratin-19 - analysis
Lung Neoplasms - diagnosis
Lung Neoplasms - diagnostic imaging
Lung Neoplasms - surgery
Male
Positron-Emission Tomography
Radiopharmaceuticals
ROC Curve
Sensitivity and Specificity
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Summary:This study evaluated the diagnostic usefulness of tumor marker concentrations in cytologic fluids (CF) for subtyping non-small cell lung cancer (NSCLC) and assessed the relationship between fluorine-18-fluorodeoxyglucose ((18)F-FDG) uptake with serum and CF tumor marker levels. This prospective study included 88 patients diagnosed with adenocarcinoma or squamous cell carcinoma (SCC). Cytokeratin-19 fragment (CYFRA 21-1), carcinoembryonic antigen (CEA), and squamous cell carcinoma antigen (SCCA) concentrations in the CF samples were correlated with serum tumor marker concentrations, (18)F-FDG uptake, and NSCLC subtype. Fifty-eight patients were diagnosed with adenocarcinoma. Multivariate analysis revealed higher CF and serum SCCA levels; smoking status predicted SCC from adenocarcinoma. CF SCCA showed the highest accuracy (83%) in distinguishing between SCC and adenocarcinoma. CF samples obtained during routine needle aspiration biopsy procedure contain tumor marker levels sufficient to distinguish between SCC and adenocarcinoma; CF SCCA had the highest diagnostic accuracy.
ISSN:0002-9173
1943-7722
DOI:10.1309/AJCPYOJYG56UNBSZ