Red blood cell transfusion in non-bleeding critically ill patients with moderate anemia: is there a benefit?

Purpose This study was undertaken to investigate the efficacy of red blood cell transfusion (RBCT) at reversing the deleterious effects of moderate anemia in critically ill, non-bleeding patients. Methods This was a retrospective, pair-matched (ratio 1:1) cohort study. Non-bleeding critically ill pa...

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Bibliographic Details
Published in:Intensive care medicine 2013-03, Vol.39 (3), p.445-453
Main Authors: Leal-Noval, Santiago R., Muñoz-Gómez, Manuel, Jiménez-Sánchez, Mercedes, Cayuela, Aurelio, Leal-Romero, María, Puppo-Moreno, Antonio, Enamorado, Judy, Arellano-Orden, Victoria
Format: Article
Language:English
Subjects:
Aged
Analysis
Anemia
Anemia - therapy
Anesthesiology
Blood
Cardiac patients
Cardiovascular disease
Clinical outcomes
Cohort analysis
Cohort Studies
Comorbidity
Critical care
Critical Care Medicine
Critical Illness
Emergency Medicine
Erythrocyte Transfusion
Female
Glycosylated hemoglobin
Health aspects
Hemoglobin
Hospital patients
Hospitals
Humans
Intensive
Male
Medical research
Medicine
Medicine & Public Health
Medicine, Experimental
Middle Aged
Mortality
Original
Pain Medicine
Pediatrics
Pneumology/Respiratory System
Retrospective Studies
Sepsis
Severity of Illness Index
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Summary:Purpose This study was undertaken to investigate the efficacy of red blood cell transfusion (RBCT) at reversing the deleterious effects of moderate anemia in critically ill, non-bleeding patients. Methods This was a retrospective, pair-matched (ratio 1:1) cohort study. Non-bleeding critically ill patients with moderate anemia (nadir hemoglobin level between 70 and 95 g/l), admitted to the ICU over a 27-month period, were included. Anemic patients were included upon meeting five matching criteria of having the same nadir hemoglobin (±5 g/l), APACHE II score (±5), SOFA score (±2), admission diagnostic group, and age (±5 years). Outcome events occurring over the whole ICU stay and after RBCT were collected. After hospital discharge, all patients had a 2-year follow-up period. Results Two hundred fourteen non-transfused anemic patients (NTAPs) were successfully matched with 214 transfused anemic patients (TAPs). In addition to the matching criteria, at baseline, both groups were homogenous with respect to multiple comorbidities. Compared with TAPs, NTAPs showed significantly lower rates of hospital mortality (21 vs.13 %, respectively; p  
ISSN:0342-4642
1432-1238
DOI:10.1007/s00134-012-2757-z