Antidepressant Abietane Diterpenoids from Chinese Eaglewood

Ten new abietane diterpenoids, aquilarabietic acids A–J (1–10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of d...

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Bibliographic Details
Published in:Journal of natural products (Washington, D.C.) D.C.), 2013-02, Vol.76 (2), p.216-222
Main Authors: Yang, Lin, Qiao, Lirui, Ji, Chengxue, Xie, Dan, Gong, Ning-Bo, Lu, Yang, Zhang, Jianjun, Dai, Jungui, Guo, Shunxing
Format: Article
Language:English
Subjects:
Animals
Antidepressive Agents - chemistry
Antidepressive Agents - isolation & purification
Antidepressive Agents - pharmacology
Brain - drug effects
Diterpenes, Abietane - chemistry
Diterpenes, Abietane - isolation & purification
Diterpenes, Abietane - pharmacology
Drugs, Chinese Herbal - chemistry
Drugs, Chinese Herbal - isolation & purification
Drugs, Chinese Herbal - pharmacology
Male
Molecular Structure
Norepinephrine - antagonists & inhibitors
Nuclear Magnetic Resonance, Biomolecular
Rats
Synaptosomes - drug effects
Thymelaeaceae - chemistry
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Summary:Ten new abietane diterpenoids, aquilarabietic acids A–J (1–10), and a new podocarpane diterpenoid, aquilarabietic acid K (11), were isolated from the petroleum ether and ethanol extracts of Chinese eaglewood. Among them, 3, 9, and 10 are artifacts. Their structures were established on the basis of data from extensive spectroscopic and X-ray diffraction analyses. Bioassay results indicated that 1 at 10 μM demonstrated remarkable antidepressant activity in vitro by inhibiting norepinephrine reuptake in rat brain synaptosomes by 81.4% and with an IC50 value of 9.1 × 10–7 M.
ISSN:0163-3864
1520-6025
DOI:10.1021/np3006925