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Secondary Hyperparathyroidism, Vitamin D Sufficiency, and Serum Calcium 5 Years After Gastric Bypass and Duodenal Switch
Background The prevalence of secondary hyperparathyroidism (SHPT) is high after bariatric surgery. Vitamin D is supplied to counteract SHPT and bone disease, and we studied vitamin D associations with SHPT. Methods We measured serum levels of 25-OH vitamin D and parathyroid hormone (PTH) 5 years aft...
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| Published in: | Obesity surgery 2013-03, Vol.23 (3), p.384-390 |
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| container_end_page | 390 |
| container_issue | 3 |
| container_start_page | 384 |
| container_title | Obesity surgery |
| container_volume | 23 |
| creator | Hewitt, Stephen Søvik, Torgeir T. Aasheim, Erlend T. Kristinsson, Jon Jahnsen, Jørgen Birketvedt, Grethe S. Bøhmer, Thomas Eriksen, Erik F. Mala, Tom |
| description | Background
The prevalence of secondary hyperparathyroidism (SHPT) is high after bariatric surgery. Vitamin D is supplied to counteract SHPT and bone disease, and we studied vitamin D associations with SHPT.
Methods
We measured serum levels of 25-OH vitamin D and parathyroid hormone (PTH) 5 years after gastric bypass and duodenal switch. One hundred twenty-five patients were included, of whom 114 (91 %) had undergone gastric bypass and 11 (9 %) had undergone duodenal switch. SHPT was defined as PTH > 7.0 pmol/l in the absence of hypercalcemia. 25-OH vitamin D levels were divided into three categories: |
| doi_str_mv | 10.1007/s11695-012-0772-3 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1312656937</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2899752111</sourcerecordid><originalsourceid>FETCH-LOGICAL-c415t-2e9970264abc28497950df2e7dbc98420e7e5ba32041d10a4f66c694702864863</originalsourceid><addsrcrecordid>eNp1kctuFDEQRS0ESoaQD8gGWcqGRZqUH223l2ECCVIkFhOQWFked3XiqF-xu4X6b_gWvgwPExBCYlULn3ur5EPICYO3DECfJ8aUKQtgvACteSGekRXTUBUgefWcrMAoKCrDxSF5mdIDAGeK8wNyyAWwkqtqRZYN-qGvXVzo9TJiHF100_0Sh1CH1J3RL2FyXejpJd3MTRN8wN4vZ9T1Nd1gnDu6dq0PeZY_vn9FFxO9aCaM9MqlKQZP3y2jS-kXfzkPNfaupZtvYfL3r8iLxrUJj5_mEfn84f3t-rq4-XT1cX1xU3jJyqngaIwGrqTbel5Jo00JdcNR11tvKskBNZZbJzhIVjNwslHKKyNzplKyUuKIvNn3jnF4nDFNtgvJY9u6Hoc5WSYYV6UyQmf09B_0YZhjPnlHARMyYyxTbE_5OKQUsbFjDF3-QcvA7rzYvRebvdidFyty5vVT87ztsP6T-C0iA3wPpPzU32H8a_V_W38C2SuXfQ</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1301345691</pqid></control><display><type>article</type><title>Secondary Hyperparathyroidism, Vitamin D Sufficiency, and Serum Calcium 5 Years After Gastric Bypass and Duodenal Switch</title><source>Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List</source><creator>Hewitt, Stephen ; Søvik, Torgeir T. ; Aasheim, Erlend T. ; Kristinsson, Jon ; Jahnsen, Jørgen ; Birketvedt, Grethe S. ; Bøhmer, Thomas ; Eriksen, Erik F. ; Mala, Tom</creator><creatorcontrib>Hewitt, Stephen ; Søvik, Torgeir T. ; Aasheim, Erlend T. ; Kristinsson, Jon ; Jahnsen, Jørgen ; Birketvedt, Grethe S. ; Bøhmer, Thomas ; Eriksen, Erik F. ; Mala, Tom</creatorcontrib><description>Background
The prevalence of secondary hyperparathyroidism (SHPT) is high after bariatric surgery. Vitamin D is supplied to counteract SHPT and bone disease, and we studied vitamin D associations with SHPT.
Methods
We measured serum levels of 25-OH vitamin D and parathyroid hormone (PTH) 5 years after gastric bypass and duodenal switch. One hundred twenty-five patients were included, of whom 114 (91 %) had undergone gastric bypass and 11 (9 %) had undergone duodenal switch. SHPT was defined as PTH > 7.0 pmol/l in the absence of hypercalcemia. 25-OH vitamin D levels were divided into three categories: <50, 50–74, and ≥75 nmol/l. Serum ionized calcium, magnesium, phosphate, and creatinine were divided into tertiles.
Results
Mean age ± SD was 44 ± 9 years at 5 years follow-up. Ninety out of 125 (72 %) patients were women. SHPT was present in 45 out of 114 (40 %) gastric bypass patients and in 11 out of 11 (100 %) duodenal switch patients. The prevalence was high in all vitamin D categories studied. An inverse association between ionized calcium and PTH was found. For the gastric bypass patients, the odds ratio for SHPT in the upper two tertiles of ionized calcium was 0.35; 95 % CI, 0.15–0.79;
p
= 0.011, compared with the lowest tertile. Supplements of vitamin D and calcium were not associated with a lower prevalence of SHPT at 5 years follow-up.
Conclusions
The prevalence of SHPT was high 5 years after gastric bypass and duodenal switch. SHPT was inversely associated with serum ionized calcium, but not with vitamin D. The supplementation used was insufficient to compensate for the impaired calcium absorption after surgery.</description><identifier>ISSN: 0960-8923</identifier><identifier>EISSN: 1708-0428</identifier><identifier>DOI: 10.1007/s11695-012-0772-3</identifier><identifier>PMID: 23015268</identifier><language>eng</language><publisher>New York: Springer-Verlag</publisher><subject>Adult ; Calcium ; Calcium - blood ; Clinical Research ; Cohort Studies ; Cross-Sectional Studies ; Duodenum - surgery ; Female ; Gastrointestinal surgery ; Gastroplasty - methods ; Hormones ; Humans ; Hyperparathyroidism, Secondary - blood ; Hyperparathyroidism, Secondary - epidemiology ; Long term ; Male ; Medicine ; Medicine & Public Health ; Middle Aged ; Norway - epidemiology ; Obesity ; Obesity, Morbid - blood ; Obesity, Morbid - epidemiology ; Postoperative Complications ; Postoperative Period ; Prevalence ; Risk Factors ; Surgery ; Time Factors ; Treatment Outcome ; Vitamin D ; Vitamin D - blood</subject><ispartof>Obesity surgery, 2013-03, Vol.23 (3), p.384-390</ispartof><rights>Springer Science + Business Media, LLC 2012</rights><rights>Springer Science+Business Media New York 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c415t-2e9970264abc28497950df2e7dbc98420e7e5ba32041d10a4f66c694702864863</citedby><cites>FETCH-LOGICAL-c415t-2e9970264abc28497950df2e7dbc98420e7e5ba32041d10a4f66c694702864863</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27903,27904</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23015268$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Hewitt, Stephen</creatorcontrib><creatorcontrib>Søvik, Torgeir T.</creatorcontrib><creatorcontrib>Aasheim, Erlend T.</creatorcontrib><creatorcontrib>Kristinsson, Jon</creatorcontrib><creatorcontrib>Jahnsen, Jørgen</creatorcontrib><creatorcontrib>Birketvedt, Grethe S.</creatorcontrib><creatorcontrib>Bøhmer, Thomas</creatorcontrib><creatorcontrib>Eriksen, Erik F.</creatorcontrib><creatorcontrib>Mala, Tom</creatorcontrib><title>Secondary Hyperparathyroidism, Vitamin D Sufficiency, and Serum Calcium 5 Years After Gastric Bypass and Duodenal Switch</title><title>Obesity surgery</title><addtitle>OBES SURG</addtitle><addtitle>Obes Surg</addtitle><description>Background
The prevalence of secondary hyperparathyroidism (SHPT) is high after bariatric surgery. Vitamin D is supplied to counteract SHPT and bone disease, and we studied vitamin D associations with SHPT.
Methods
We measured serum levels of 25-OH vitamin D and parathyroid hormone (PTH) 5 years after gastric bypass and duodenal switch. One hundred twenty-five patients were included, of whom 114 (91 %) had undergone gastric bypass and 11 (9 %) had undergone duodenal switch. SHPT was defined as PTH > 7.0 pmol/l in the absence of hypercalcemia. 25-OH vitamin D levels were divided into three categories: <50, 50–74, and ≥75 nmol/l. Serum ionized calcium, magnesium, phosphate, and creatinine were divided into tertiles.
Results
Mean age ± SD was 44 ± 9 years at 5 years follow-up. Ninety out of 125 (72 %) patients were women. SHPT was present in 45 out of 114 (40 %) gastric bypass patients and in 11 out of 11 (100 %) duodenal switch patients. The prevalence was high in all vitamin D categories studied. An inverse association between ionized calcium and PTH was found. For the gastric bypass patients, the odds ratio for SHPT in the upper two tertiles of ionized calcium was 0.35; 95 % CI, 0.15–0.79;
p
= 0.011, compared with the lowest tertile. Supplements of vitamin D and calcium were not associated with a lower prevalence of SHPT at 5 years follow-up.
Conclusions
The prevalence of SHPT was high 5 years after gastric bypass and duodenal switch. SHPT was inversely associated with serum ionized calcium, but not with vitamin D. The supplementation used was insufficient to compensate for the impaired calcium absorption after surgery.</description><subject>Adult</subject><subject>Calcium</subject><subject>Calcium - blood</subject><subject>Clinical Research</subject><subject>Cohort Studies</subject><subject>Cross-Sectional Studies</subject><subject>Duodenum - surgery</subject><subject>Female</subject><subject>Gastrointestinal surgery</subject><subject>Gastroplasty - methods</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hyperparathyroidism, Secondary - blood</subject><subject>Hyperparathyroidism, Secondary - epidemiology</subject><subject>Long term</subject><subject>Male</subject><subject>Medicine</subject><subject>Medicine & Public Health</subject><subject>Middle Aged</subject><subject>Norway - epidemiology</subject><subject>Obesity</subject><subject>Obesity, Morbid - blood</subject><subject>Obesity, Morbid - epidemiology</subject><subject>Postoperative Complications</subject><subject>Postoperative Period</subject><subject>Prevalence</subject><subject>Risk Factors</subject><subject>Surgery</subject><subject>Time Factors</subject><subject>Treatment Outcome</subject><subject>Vitamin D</subject><subject>Vitamin D - blood</subject><issn>0960-8923</issn><issn>1708-0428</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kctuFDEQRS0ESoaQD8gGWcqGRZqUH223l2ECCVIkFhOQWFked3XiqF-xu4X6b_gWvgwPExBCYlULn3ur5EPICYO3DECfJ8aUKQtgvACteSGekRXTUBUgefWcrMAoKCrDxSF5mdIDAGeK8wNyyAWwkqtqRZYN-qGvXVzo9TJiHF100_0Sh1CH1J3RL2FyXejpJd3MTRN8wN4vZ9T1Nd1gnDu6dq0PeZY_vn9FFxO9aCaM9MqlKQZP3y2jS-kXfzkPNfaupZtvYfL3r8iLxrUJj5_mEfn84f3t-rq4-XT1cX1xU3jJyqngaIwGrqTbel5Jo00JdcNR11tvKskBNZZbJzhIVjNwslHKKyNzplKyUuKIvNn3jnF4nDFNtgvJY9u6Hoc5WSYYV6UyQmf09B_0YZhjPnlHARMyYyxTbE_5OKQUsbFjDF3-QcvA7rzYvRebvdidFyty5vVT87ztsP6T-C0iA3wPpPzU32H8a_V_W38C2SuXfQ</recordid><startdate>20130301</startdate><enddate>20130301</enddate><creator>Hewitt, Stephen</creator><creator>Søvik, Torgeir T.</creator><creator>Aasheim, Erlend T.</creator><creator>Kristinsson, Jon</creator><creator>Jahnsen, Jørgen</creator><creator>Birketvedt, Grethe S.</creator><creator>Bøhmer, Thomas</creator><creator>Eriksen, Erik F.</creator><creator>Mala, Tom</creator><general>Springer-Verlag</general><general>Springer Nature B.V</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7X7</scope><scope>7XB</scope><scope>88E</scope><scope>8AO</scope><scope>8C1</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>BENPR</scope><scope>CCPQU</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>K9.</scope><scope>M0S</scope><scope>M1P</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>7X8</scope></search><sort><creationdate>20130301</creationdate><title>Secondary Hyperparathyroidism, Vitamin D Sufficiency, and Serum Calcium 5 Years After Gastric Bypass and Duodenal Switch</title><author>Hewitt, Stephen ; Søvik, Torgeir T. ; Aasheim, Erlend T. ; Kristinsson, Jon ; Jahnsen, Jørgen ; Birketvedt, Grethe S. ; Bøhmer, Thomas ; Eriksen, Erik F. ; Mala, Tom</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c415t-2e9970264abc28497950df2e7dbc98420e7e5ba32041d10a4f66c694702864863</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Calcium</topic><topic>Calcium - blood</topic><topic>Clinical Research</topic><topic>Cohort Studies</topic><topic>Cross-Sectional Studies</topic><topic>Duodenum - surgery</topic><topic>Female</topic><topic>Gastrointestinal surgery</topic><topic>Gastroplasty - methods</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hyperparathyroidism, Secondary - blood</topic><topic>Hyperparathyroidism, Secondary - epidemiology</topic><topic>Long term</topic><topic>Male</topic><topic>Medicine</topic><topic>Medicine & Public Health</topic><topic>Middle Aged</topic><topic>Norway - epidemiology</topic><topic>Obesity</topic><topic>Obesity, Morbid - blood</topic><topic>Obesity, Morbid - epidemiology</topic><topic>Postoperative Complications</topic><topic>Postoperative Period</topic><topic>Prevalence</topic><topic>Risk Factors</topic><topic>Surgery</topic><topic>Time Factors</topic><topic>Treatment Outcome</topic><topic>Vitamin D</topic><topic>Vitamin D - blood</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Hewitt, Stephen</creatorcontrib><creatorcontrib>Søvik, Torgeir T.</creatorcontrib><creatorcontrib>Aasheim, Erlend T.</creatorcontrib><creatorcontrib>Kristinsson, Jon</creatorcontrib><creatorcontrib>Jahnsen, Jørgen</creatorcontrib><creatorcontrib>Birketvedt, Grethe S.</creatorcontrib><creatorcontrib>Bøhmer, Thomas</creatorcontrib><creatorcontrib>Eriksen, Erik F.</creatorcontrib><creatorcontrib>Mala, Tom</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Health & Medical Collection</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>Medical Database (Alumni Edition)</collection><collection>ProQuest Pharma Collection</collection><collection>Public Health Database</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central UK/Ireland</collection><collection>ProQuest Central</collection><collection>ProQuest One Community College</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Health & Medical Collection (Alumni Edition)</collection><collection>Medical Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>MEDLINE - Academic</collection><jtitle>Obesity surgery</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Hewitt, Stephen</au><au>Søvik, Torgeir T.</au><au>Aasheim, Erlend T.</au><au>Kristinsson, Jon</au><au>Jahnsen, Jørgen</au><au>Birketvedt, Grethe S.</au><au>Bøhmer, Thomas</au><au>Eriksen, Erik F.</au><au>Mala, Tom</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Secondary Hyperparathyroidism, Vitamin D Sufficiency, and Serum Calcium 5 Years After Gastric Bypass and Duodenal Switch</atitle><jtitle>Obesity surgery</jtitle><stitle>OBES SURG</stitle><addtitle>Obes Surg</addtitle><date>2013-03-01</date><risdate>2013</risdate><volume>23</volume><issue>3</issue><spage>384</spage><epage>390</epage><pages>384-390</pages><issn>0960-8923</issn><eissn>1708-0428</eissn><abstract>Background
The prevalence of secondary hyperparathyroidism (SHPT) is high after bariatric surgery. Vitamin D is supplied to counteract SHPT and bone disease, and we studied vitamin D associations with SHPT.
Methods
We measured serum levels of 25-OH vitamin D and parathyroid hormone (PTH) 5 years after gastric bypass and duodenal switch. One hundred twenty-five patients were included, of whom 114 (91 %) had undergone gastric bypass and 11 (9 %) had undergone duodenal switch. SHPT was defined as PTH > 7.0 pmol/l in the absence of hypercalcemia. 25-OH vitamin D levels were divided into three categories: <50, 50–74, and ≥75 nmol/l. Serum ionized calcium, magnesium, phosphate, and creatinine were divided into tertiles.
Results
Mean age ± SD was 44 ± 9 years at 5 years follow-up. Ninety out of 125 (72 %) patients were women. SHPT was present in 45 out of 114 (40 %) gastric bypass patients and in 11 out of 11 (100 %) duodenal switch patients. The prevalence was high in all vitamin D categories studied. An inverse association between ionized calcium and PTH was found. For the gastric bypass patients, the odds ratio for SHPT in the upper two tertiles of ionized calcium was 0.35; 95 % CI, 0.15–0.79;
p
= 0.011, compared with the lowest tertile. Supplements of vitamin D and calcium were not associated with a lower prevalence of SHPT at 5 years follow-up.
Conclusions
The prevalence of SHPT was high 5 years after gastric bypass and duodenal switch. SHPT was inversely associated with serum ionized calcium, but not with vitamin D. The supplementation used was insufficient to compensate for the impaired calcium absorption after surgery.</abstract><cop>New York</cop><pub>Springer-Verlag</pub><pmid>23015268</pmid><doi>10.1007/s11695-012-0772-3</doi><tpages>7</tpages><oa>free_for_read</oa></addata></record> |
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| ispartof | Obesity surgery, 2013-03, Vol.23 (3), p.384-390 |
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| source | Springer Nature:Jisc Collections:Springer Nature Read and Publish 2023-2025: Springer Reading List |
| subjects | Adult Calcium Calcium - blood Clinical Research Cohort Studies Cross-Sectional Studies Duodenum - surgery Female Gastrointestinal surgery Gastroplasty - methods Hormones Humans Hyperparathyroidism, Secondary - blood Hyperparathyroidism, Secondary - epidemiology Long term Male Medicine Medicine & Public Health Middle Aged Norway - epidemiology Obesity Obesity, Morbid - blood Obesity, Morbid - epidemiology Postoperative Complications Postoperative Period Prevalence Risk Factors Surgery Time Factors Treatment Outcome Vitamin D Vitamin D - blood |
| title | Secondary Hyperparathyroidism, Vitamin D Sufficiency, and Serum Calcium 5 Years After Gastric Bypass and Duodenal Switch |
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