The Coming Age of Complete, Accurate, and Ubiquitous Proteomes

High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours. Developments discussed in this Perspective will soon enable complete proteome analysis of mammalian cells, a...

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Bibliographic Details
Published in:Molecular cell 2013-02, Vol.49 (4), p.583-590
Main Authors: Mann, Matthias, Kulak, Nils A., Nagaraj, Nagarjuna, Cox, Jürgen
Format: Article
Language:English
Subjects:
Animals
Cells, Cultured
Computational Biology
Fungal Proteins - analysis
Fungal Proteins - chemistry
Fungal Proteins - isolation & purification
Humans
mammals
Mass Spectrometry
medicine
proteome
Proteome - analysis
Proteome - chemistry
Proteome - isolation & purification
Proteomics
yeasts
Yeasts - chemistry
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Summary:High-resolution mass spectrometry (MS)-based proteomics has progressed tremendously over the years. For model organisms like yeast, we can now quantify complete proteomes in just a few hours. Developments discussed in this Perspective will soon enable complete proteome analysis of mammalian cells, as well, with profound impact on biology and biomedicine.
ISSN:1097-2765
1097-4164
DOI:10.1016/j.molcel.2013.01.029