A single mesoporous ZnO/Chitosan hybrid nanostructure for a novel free nanoprobe type biosensor

A novel method of fabricating a free probe type nanoscale biosensor is first demonstrated. A free probe type biosensor based on a single one-dimensional (1D) mesoporous ZnO/Chitosan inorganic–organic hybrid nanostructure is constructed. The as-prepared biosensor exhibited excellent biosensing perfor...

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Bibliographic Details
Published in:Biosensors & bioelectronics 2013-05, Vol.43, p.226-230
Main Authors: Zhao, Minggang, Huang, Jingyun, Zhou, Yu, Chen, Qi, Pan, Xinhua, He, Haiping, Ye, Zhizhen
Format: Article
Language:English
Subjects:
Biological and medical sciences
Biosensing Techniques - instrumentation
Biosensor
Biosensors
Biotechnology
Chitosan - chemistry
Conductometry - instrumentation
Equipment Design
Equipment Failure Analysis
Free probe
Fundamental and applied biological sciences. Psychology
Hybrid
Inorganic–organic
Methods. Procedures. Technologies
Molecular Probe Techniques - instrumentation
Nanostructures - chemistry
Nanostructures - ultrastructure
Porosity
Single mesoporous ZnO
Various methods and equipments
Zinc Oxide - chemistry
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Summary:A novel method of fabricating a free probe type nanoscale biosensor is first demonstrated. A free probe type biosensor based on a single one-dimensional (1D) mesoporous ZnO/Chitosan inorganic–organic hybrid nanostructure is constructed. The as-prepared biosensor exhibited excellent biosensing performance and was stable in solution due to its inorganic–organic hybrid structure. The special mesoporous nanostructure with protuberances favors enzymes loading and enhances electrical communication efficiency. The feasibility of employing a single 1D nanostructure as a separate free nanoprobe for biosensing is demonstrated. This kind of free probe type biosensor will not only provides a new tool for micro-targets detection in microcell and enzymatic studies, but also has the potential to be inserted into single cell or other microorganism for biological studies. ► Single mesoporous ZnO/Chitosan hybrid nanostructure was fabricated. ► Free probe type nanoscale biosensor based nanostructure is demonstrated. ► As-prepared biosensor exhibited excellent biosensing performance and stability. ► This biosensor will provide a new tool for micro-targets detection in microcell and cellular studies.
ISSN:0956-5663
1873-4235
DOI:10.1016/j.bios.2012.11.041