Association of TGF-β1 −509 C/T, 29 C/T and 788 C/T gene polymorphisms with chronic periodontitis: A case–control study

The aim of this study was to investigate the possible association between TGF-β1 −509 C/T (rs1800469), 29 C/T (Prol10Leu, rs1800470) and 788 C/T (Thr263Ile, rs1800472) gene polymorphisms and chronic periodontitis (CP) in a sample of Iranian population. This case–control study was conducted on 100 CP...

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Bibliographic Details
Published in:Gene 2013-04, Vol.518 (2), p.330-334
Main Authors: Heidari, Zahra, Mahmoudzadeh-Sagheb, Hamidreza, Rigi-Ladiz, Mohammad Ayub, Taheri, Mohsen, Moazenni-Roodi, Abdolkarim, Hashemi, Mohammad
Format: Article
Language:English
Subjects:
Adult
Alleles
Case-Control Studies
Chronic periodontitis
Chronic Periodontitis - genetics
Female
Gene Frequency
Gene polymorphism
Genetic Association Studies
Genetic Predisposition to Disease
Genotype
genotyping
Humans
Iran
Male
mutation
patients
Polymorphism, Single Nucleotide
Risk
T-ARMS-PCR
TGF-β1
transforming growth factor beta 1
Transforming Growth Factor beta1 - genetics
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Summary:The aim of this study was to investigate the possible association between TGF-β1 −509 C/T (rs1800469), 29 C/T (Prol10Leu, rs1800470) and 788 C/T (Thr263Ile, rs1800472) gene polymorphisms and chronic periodontitis (CP) in a sample of Iranian population. This case–control study was conducted on 100 CP patients and 100 healthy unrelated, age-, sex-, and ethnicity-matched. Genotyping was performed by tetra amplification refractory mutation system-polymerase chain reaction (T-ARMS-PCR) technique. Our findings showed that there was a significant difference between the groups regarding TGF-β1 29 C/T (rs1800470) polymorphism (χ2=23.23, P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2012.12.108