Complexity of the Relation Between Hemoglobin A1C, Diabetes Mellitus, and Progression of Coronary Narrowing in Postmenopausal Women

The aim of this study was to assess the effect of diabetes mellitus (DM) and glycosylated hemoglobin (HbA1c ) on the progression of atherosclerosis in postmenopausal women. A retrospective analysis of the Women’s Angiographic and Vitamin and Estrogen (WAVE) trial, a multicenter randomized trial on p...

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Bibliographic Details
Published in:The American journal of cardiology 2013-03, Vol.111 (6), p.793-799
Main Authors: Ahmad, Soha, MD, Xue, Zhenyi, MS, Silverman, Angela, MSN, Lindsay, Joseph, MD
Format: Article
Language:English
Subjects:
Aged
Canada
Cardiovascular
Cardiovascular disease
Cholesterol
Coronary Artery Disease - metabolism
Coronary vessels
Diabetes
Diabetes Mellitus - metabolism
Disease Progression
Female
Glycated Hemoglobin A - metabolism
Heart attacks
Humans
Middle Aged
Ovariectomy
Postmenopause
Retrospective Studies
Risk Factors
United States
Women
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Summary:The aim of this study was to assess the effect of diabetes mellitus (DM) and glycosylated hemoglobin (HbA1c ) on the progression of atherosclerosis in postmenopausal women. A retrospective analysis of the Women’s Angiographic and Vitamin and Estrogen (WAVE) trial, a multicenter randomized trial on progression of atherosclerosis in postmenopausal women, was performed. Baseline and follow-up angiography was performed in 320 women. Minimum luminal diameter and average luminal diameter at baseline and follow-up were measured in 1,735 coronary segments. Measurements and adverse events were grouped on the basis of history of DM and HbA1c . DM was associated with more total cardiac events but with similar rates of death or myocardial infarction. There were greater reductions in minimum luminal diameter and average luminal diameter in segments from patients with known DM (p
ISSN:0002-9149
1879-1913
DOI:10.1016/j.amjcard.2012.11.057