82Sr purification procedure using Chelex-100 resin

82Rb is a positron-emitting radionuclide widely used in nuclear cardiology. One great advantage is its availability through a generator loaded with 82Sr. 82Sr can be produced in a high energy cyclotron by irradiating rubidium chloride target with proton beam. In this paper, we present an extensive s...

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Bibliographic Details
Published in:Applied radiation and isotopes 2013-04, Vol.74, p.56-60
Main Authors: Alliot, C., Audouin, N., Bonraisin, A.C., Bossé, V., Laizé, J., Bourdeau, C., Mokili, B.M., Michel, N., Haddad, F.
Format: Article
Language:English
Subjects:
82Rb
82Sr
Automation
Chlorides - radiation effects
Chromatography, Ion Exchange - methods
Coronary Artery Disease - diagnostic imaging
Cyclotrons
Electrons
Flow rate
Humans
Purification
Radionuclide Generators - instrumentation
Radionuclide Imaging
Radiopharmaceuticals - isolation & purification
Resins, Synthetic
Rubidium - radiation effects
Strontium Radioisotopes - isolation & purification
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Summary:82Rb is a positron-emitting radionuclide widely used in nuclear cardiology. One great advantage is its availability through a generator loaded with 82Sr. 82Sr can be produced in a high energy cyclotron by irradiating rubidium chloride target with proton beam. In this paper, we present an extensive study (elution profiles, effect of the elution flow rate) on the use of Chelex-100 resin and ammonia buffer. No significant effect of flow rate was evidenced between 1 and 10mL/min leading us to propose a purification process which can be easily automated. ► The final solution of 82Sr can be used for loading generator. ► The flow rate can be increased up to 10mL/min. ► The purification process can be also automated.
ISSN:0969-8043
1872-9800
DOI:10.1016/j.apradiso.2012.10.020