New insights into the role of NF1 in cancer

NF1 proteins are a family of transcription factors that act either as repressors or as activators. Functional studies indicate that NF1 participate in signaling pathways that regulate cell viability, proliferation and differentiation. Participation in regulation of genes important for tumor progress...

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Bibliographic Details
Published in:Neoplasma 2013, Vol.60 (3), p.233-239
Main Authors: Sabova, L, Kretova, M, Luciakova, K
Format: Article
Language:English
Subjects:
Humans
Neoplasms - diagnosis
Neoplasms - metabolism
Neoplasms - therapy
Neurofibromin 1 - metabolism
Signal Transduction
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Summary:NF1 proteins are a family of transcription factors that act either as repressors or as activators. Functional studies indicate that NF1 participate in signaling pathways that regulate cell viability, proliferation and differentiation. Participation in regulation of genes important for tumor progression and metastasizing suggests a potential value of NF1 as a prognostic factor for certain types of cancer.
ISSN:0028-2685
DOI:10.4149/neo_2013_031