Vitamin D Deficiency Is Associated With Increased Left Ventricular Mass and Diastolic Dysfunction in Children With Chronic Kidney Disease

• Published in: Pediatric cardiology 2013-03, Vol.34 (3), p.536-542
• Main Authors: Patange, Amit R., Valentini, Rudolph P., Gothe, Mayuri P., Du, Wei, Pettersen, Michael D.
• Format: Article
• Language: English
• Subjects: Adolescent; Age Distribution; Alfacalcidol; Analysis of Variance; Calcifediol; Cardiac Surgery; Cardiology; Cardiovascular diseases; Child; Children; Children's furniture; Chronic kidney failure; Comorbidity; Cross-Sectional Studies; Echocardiography - methods; Female; Health aspects; Heart Failure, Diastolic - diagnostic imaging; Heart Failure, Diastolic - epidemiology; Humans; Hypertrophy, Left Ventricular - diagnostic imaging; Hypertrophy, Left Ventricular - epidemiology; Incidence; Male; Medical research; Medicine; Medicine & Public Health; Medicine, Experimental; Multivariate Analysis; Original Article; Physiological aspects; Prognosis; Regression Analysis; Renal Dialysis - methods; Renal Insufficiency, Chronic - diagnosis; Renal Insufficiency, Chronic - epidemiology; Renal Insufficiency, Chronic - therapy; Severity of Illness Index; Sex Distribution; Survival Analysis; Vascular Surgery; Vitamin D; Vitamin D deficiency; Vitamin D Deficiency - diagnosis; Vitamin D Deficiency - epidemiology
• ISSN: 0172-0643; 1432-1971
• DOI: 10.1007/s00246-012-0489-z

Cardiovascular disease currently is the leading cause of morbidity and mortality among patients with chronic kidney disease (CKD). Abnormalities in arterial compliance, increased left ventricular mass, and diastolic dysfunction are some of the recognized cardiovascular complications observed in these patients. This study explored the relationship between various parameters of calcium-phosphorus metabolism including 25-hydroxy vitamin D and cardiovascular structure and function in pediatric patients with CKD. This cross-sectional study was conducted using a cohort of 34 children with CKD who had no history of underlying congenital or structural cardiac disease. Two-dimensional echocardiography was used to measure the left ventricular mass index (LVMI), E/A ratio, E ′, E/E ′ ratio, and myocardial performance index (MPI). The augmentation index (AI), derived via radial artery tonometry, was used as an indirect measure of central aortic stiffness. Serum biochemical markers of calcium-phosphorus metabolism were simultaneously measured. Univariate analysis showed that LVMI correlated with 25-hydroxy vitamin D ( r  = –0.54; p