In vitro tumor cytotoxic activities of extracts from three Liriodendron plants

The extracts prepared from Liriodendron tulipifera Linn., L. chinense (Hemsl.) Sarg., and their hybrid L. chinense x L. tulipifera, were investigated for their cytotoxic abilities in vitro against five human cancer cell lines: MDA-MB-231 and MCF-7 breast cancer cells, SGC-7901 gastric cancer cells,...

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Bibliographic Details
Published in:Pakistan journal of pharmaceutical sciences 2013-03, Vol.26 (2), p.233-237
Main Authors: Chen, Jin-Hui, Yang, Guo-Xu, Ding, Qiang, Xia, Tian-Song, Shi, Jisen, Jia, Ai-Qun
Format: Article
Language:English
Subjects:
Alkaloids - analysis
Alkaloids - isolation & purification
Alkaloids - pharmacology
Antineoplastic Agents, Phytogenic - analysis
Antineoplastic Agents, Phytogenic - isolation & purification
Antineoplastic Agents, Phytogenic - pharmacology
Cancer
Care and treatment
Cell Survival - drug effects
Chemical properties
Dose-Response Relationship, Drug
Humans
Identification and classification
Inhibitory Concentration 50
Liriodendron - chemistry
Materia medica, Vegetable
MCF-7 Cells
Neoplasms - pathology
Phenols - analysis
Phenols - isolation & purification
Phenols - pharmacology
Phytochemistry
Plant Bark
Plant extracts
Plant Extracts - analysis
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Leaves
Plants, Medicinal
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Summary:The extracts prepared from Liriodendron tulipifera Linn., L. chinense (Hemsl.) Sarg., and their hybrid L. chinense x L. tulipifera, were investigated for their cytotoxic abilities in vitro against five human cancer cell lines: MDA-MB-231 and MCF-7 breast cancer cells, SGC-7901 gastric cancer cells, HuH-7 hepatocarcinoma cells, and HCT-15 colon carcinoma cells, and then measured their phenols and alkaloids contents. Of these plant extracts, some of them, especially the lower polar extracts from barks, exhibited potent cytotoxic effects on five tested tumor cell lines.
ISSN:1011-601X