A Life‐Threatening Flecainide Overdose Treated with Intravenous Fat Emulsion

Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life‐threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarb...

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Bibliographic Details
Published in:Pacing and clinical electrophysiology 2013-03, Vol.36 (3), p.e87-e89
Main Authors: ELLSWORTH, HEATHER, STELLPFLUG, SAMUEL J., COLE, JON B., DOLAN, JOSEPH A., HARRIS, CARSON R.
Format: Article
Language:English
Subjects:
Anti-Arrhythmia Agents - poisoning
Drug Overdose - therapy
electrocardiogram
Emergency Treatment
Fat Emulsions, Intravenous - therapeutic use
Flecainide - poisoning
hemodynamics
Humans
long QT
Male
Middle Aged
pharmacology
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Summary:Flecainide is a Vaughan Williams Class Ic antidysrhythmic associated with PR, QRS, and QTc prolongation on the electrocardiogram and development of life‐threatening cardiac toxicity in overdose. The cornerstone of treatment is fluid resuscitation and the administration of magnesium and sodium bicarbonate. We report a case of flecainide overdose associated with life‐threatening hemodynamic compromise successfully treated with intravenous fat emulsion (IFE) therapy. IFE should be considered as a novel adjunctive therapy in patients with life‐threatening toxicity following flecainide overdose.
ISSN:0147-8389
1540-8159
DOI:10.1111/j.1540-8159.2012.03485.x