Association of FGFR3 and MDM2 Gene Nucleotide Polymorphisms with Bone Tumors

Association study of 6 candidate single-nucleotide polymorphisms (rs7921, rs7956547, rs3761243, rs11737764, rs6599400, rs1690916) was carried out in a group of patients with bone tumors of different histological structure ( n =68) and control group of normal subjects ( n =96). Significant associatio...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2012-10, Vol.153 (6), p.870-874
Main Authors: Naumov, V. A., Generozov, E. V., Solovyov, Yu. N., Aliev, M. D., Kushlinsky, N. E.
Format: Article
Language:English
Subjects:
Biomedical and Life Sciences
Biomedicine
Bone tumors
Cell Biology
Development and progression
Fibroblast growth factors
Genes
Genetic aspects
Genomics
Internal Medicine
Laboratory Medicine
Oncology
Pathology
Protein binding
Sarcoma
Single nucleotide polymorphisms
Tumor proteins
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Summary:Association study of 6 candidate single-nucleotide polymorphisms (rs7921, rs7956547, rs3761243, rs11737764, rs6599400, rs1690916) was carried out in a group of patients with bone tumors of different histological structure ( n =68) and control group of normal subjects ( n =96). Significant associations of rs6599400 and rs1690916 polymorphisms with disease risk were detected (odds ratio 2.15 [1.06-4.24] and 0.39 [0.19-0.78], respectively). These polymorphisms were located in untranslated genome regions: polymorphism rs6599400 in the 5’ region of fibroblast growth factor-3 receptor gene ( FGFR3 ), rs1690916 in the 3’ region of mouse MDM2 p53-binding protein homolog ( MDM2 ). These data indicated a possible role of hereditary genetic factors in the formation of predisposition to bone sarcomas and confirmed previous findings according to which these genes should be regarded among the most probable factors involved in tumor development, including tumors of the bone and cartilage tissues.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-012-1847-9