Osteoclast-like giant cell tumor of the pancreas: an immunohistochemical and ultrastructural study

We report a rare case of osteoclast-like giant cell tumor of the pancreas in a 70-year-old Japanese woman. The tumor was composed of a proliferation of ovoid to spindle-shaped mononuclear cells admixed with osteoclast-like giant cells. The tumor cells were immunore-active for vimentin, plus or minus...

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Bibliographic Details
Published in:Medical Electron Microscopy 1997-12, Vol.30 (4), p.216-220, Article 216
Main Authors: Suzuki, Fujihiko, Saito, Akira, Ishi, Kazuhisa, Yamanaka, Koichiro, Maruyama, Toshihide, Fukunaga, Masaki, Matsumoto, Michio, Eguchi, Masanobu, Hosokawa, Yoshinori, Suda, Koichi
Format: Article
Language:English
Subjects:
Bone
Bone tumors
Cell proliferation
Differentiation
Electron microscopy
Giant cells
Leukocytes (mononuclear)
Osteoclasts
Pancreas
stromal cells
Tumor cells
Tumors
Vimentin
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Summary:We report a rare case of osteoclast-like giant cell tumor of the pancreas in a 70-year-old Japanese woman. The tumor was composed of a proliferation of ovoid to spindle-shaped mononuclear cells admixed with osteoclast-like giant cells. The tumor cells were immunore-active for vimentin, plus or minus sub(1)-antitrypsin, and CD68. In ultrastructural examination, the giant cells resembled osteoclasts, and the mononuclear stromal cells had fibroblastic and histiocytic features. No elements of epithelial differentiation were found in this tumor. These findings suggest that this tumor had a derivation similar to giant cell tumor of bone.
ISSN:0918-4287
1437-773X
1860-1499
DOI:10.1007/BF01545773