Analysis of the genetic effects of prolactin gene polymorphisms on chicken egg production

Chicken prolactin (PRL) is a physiological candidate gene for egg production. Variations of T8052C and G8113C in exon 5 of PRL gene may associate with chicken egg production. The objective of the study was to investigate the association of these two single nucleotide polymorphisms in PRL gene with e...

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Bibliographic Details
Published in:Molecular biology reports 2013, Vol.40 (1), p.289-294
Main Authors: Li, Hui-Fang, Shu, Jing-Ting, Du, Yu-Feng, Shan, Yan-Ju, Chen, Kuan-Wei, Zhang, Xue-Yu, Han, Wei, Xu, Wen-Juan
Format: Article
Language:English
Subjects:
Alleles
Animal Anatomy
Animal Biochemistry
Animals
Biomedical and Life Sciences
Chickens - physiology
Eggs
Female
Gene expression
Gene Frequency
Genotype
Haplotypes
Histology
Life Sciences
Morphology
Polymorphism
Polymorphism, Genetic
Polymorphism, Single Nucleotide
Prolactin - genetics
Quantitative Trait, Heritable
Reproduction - genetics
Transgenic animals
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Summary:Chicken prolactin (PRL) is a physiological candidate gene for egg production. Variations of T8052C and G8113C in exon 5 of PRL gene may associate with chicken egg production. The objective of the study was to investigate the association of these two single nucleotide polymorphisms in PRL gene with egg production of Recessive White chickens and Qingyuan Partridge chickens. Genotyping was performed by polymerase chain reaction-ligase detection reaction (PCR-LDR) method. The T8052C and G8113C of PRL were significantly associated with age at first egg (AFE) and total egg number at 300 days of age (EN 300). A significant association was also found between T8052C–G8113C haplotypes and AFE as well as EN300, the H2H3 was the most advantageous diplotype for egg production. We putatively drew the conclusion that these two SNPs in PRL gene as well as their haplotypes could be used as the potential molecular markers for egg production traits in chicken.
ISSN:0301-4851
1573-4978
DOI:10.1007/s11033-012-2060-7