Intramucosal bacteria in colon cancer and their elimination by probiotic strainEnterococcus faecium M-74 with organic selenium

Intraepithelial bacteria were isolated by the gentamicin protection assay (GPA) from biopsy samples obtained at colonoscopy (colon cancer,n=10 patients; colonic adenoma,n=20; control group,n=20; cancer patients without gastrointestinal tract GIT malignancy,n=10). After a three-month administration o...

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Bibliographic Details
Published in:Folia microbiologica 2005-09, Vol.50 (5), p.443-447, Article 443
Main Authors: Mego, M, Májek, J, Končeková, R, Ebringer, L, Čierniková, S, Rauko, P, Kováč, M, Trupl, J, Slezák, P, Zajac, V
Format: Article
Language:English
Subjects:
Adenoma
Bacteria
Biopsy
Carcinoma
Colon
Colon cancer
Colonoscopy
Colorectal cancer
Gastrointestinal system
Gastrointestinal tract
Gentamicin
Inflammatory bowel disease
Inflammatory bowel diseases
Intestine
Intracellular
Malignancy
Probiotics
Selenium
Tumors
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Summary:Intraepithelial bacteria were isolated by the gentamicin protection assay (GPA) from biopsy samples obtained at colonoscopy (colon cancer,n=10 patients; colonic adenoma,n=20; control group,n=20; cancer patients without gastrointestinal tract GIT malignancy,n=10). After a three-month administration ofE. faecium M-74 to patients with positive GPA biopsies, 172 biopsy specimens from 60 patients were examined with the GPA. The number of biopsies with intracellular bacteria was significantly higher in adenoma and carcinoma group than in control group (26vs. 10 %;p=0.004); in cancer patients without GIT malignancy the difference was nonsignificant.E. faecium M-74 was also administered to 5 patients with colonic adenoma; according to a control colonoscopy the number of biopsies with intracellular bacteria was significantly lower after probiotic administration (48vs. 16 %;p=0.03). A striking prevalence of intraepithelial bacteria was also showed in patients with large bowel adenoma and carcinoma. The administration of probiotic strain M-74 can thus be considered to be an effective and promising method for elimination of pathogenic bacteria in the case of inflammatory bowel disease and colon cancer.
ISSN:0015-5632
1874-9356
DOI:10.1007/BF02931427