Regulation of cardiac oxidative stress and lipid peroxidation in streptozotocin-induced diabetic rats treated with aqueous extract of Pimpinella tirupatiensis tuberous root

Plants with antidiabetic activities provide important source for the development of new drugs in the management of diabetes mellitus. The main aim of this study was to evaluate the protective effect of aqueous extract (AE) of Pimpinella tirupatiensis (Pt) tuberous root on cardiac oxidative stress an...

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Bibliographic Details
Published in:Experimental and toxicologic pathology : official journal of the Gesellschaft für Toxikologische Pathologie 2013-01, Vol.65 (1-2), p.15-19
Main Authors: Saddala, Rajeswara Reddy, Thopireddy, Lavanya, Ganapathi, Narasimhulu, Kesireddy, Sathyavelu Reddy
Format: Article
Language:English
Subjects:
Animals
Antioxidants - metabolism
ascorbic acid
Blood Glucose - analysis
Cardiac tissue
defense mechanisms
Diabetes
diabetes mellitus
Diabetes Mellitus, Experimental - drug therapy
Diabetes Mellitus, Experimental - metabolism
glibenclamide
glutathione
Glyburide - pharmacology
glycemic effect
GSH
heart
hyperglycemia
Hypoglycemic Agents - isolation & purification
Hypoglycemic Agents - pharmacology
Hypoglycemic Agents - therapeutic use
Lipid Peroxidation
Male
malondialdehyde
Malondialdehyde - blood
MDA
Myocardium - metabolism
new drugs
Oxidative stress
Oxidative Stress - drug effects
Pimpinella
Pimpinella - chemistry
Pimpinella tirupatiensis
Plant Extracts - isolation & purification
Plant Extracts - pharmacology
Plant Extracts - therapeutic use
Plant Roots - chemistry
protective effect
Rats
Rats, Wistar
Streptozocin - pharmacology
streptozotocin
uric acid
Water - chemistry
xanthine oxidase
XOD
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Summary:Plants with antidiabetic activities provide important source for the development of new drugs in the management of diabetes mellitus. The main aim of this study was to evaluate the protective effect of aqueous extract (AE) of Pimpinella tirupatiensis (Pt) tuberous root on cardiac oxidative stress and lipid peroxidation (LPO) in non-diabetic and streptozotocin (STZ)-induced diabetic rats. Diabetes was induced in male Wistar rats by a single administration of STZ (40mg/kg intraperitoneal (i.p). AE (750mg/kg/b.w./day) and glibenclamide (GLB) (20mg/kg/b.w./day) were administrated orally by intra oral gastric tube for 30 days. After 4 weeks of hyperglycaemia the enzymatic and non-enzymatic factors were measured in cardiac tissue of diabetic and control groups. Xanthine oxidase activity (XOD), Uric acid (UA) and malondialdehyde (MDA) content were significantly (p
ISSN:0940-2993
1618-1433
DOI:10.1016/j.etp.2011.05.003