Contribution of JAK2 and STAT3 variants to the genetic susceptibility of recurrent miscarriage among Bahraini and Tunisian Arabs

• Published in: Molecular biology reports 2013, Vol.40 (1), p.585-589
• Main Authors: Messoudi, Safia, Al-Sulaiti, Manar A., Al-Busaidi, Amna S., Dendana, Maryam, Nsiri, Brahim, Almawi, Wassim Y., Mahjoub, Touhami
• Format: Article
• Language: English
• Subjects: Abortion, Habitual - ethnology; Abortion, Habitual - genetics; Adult; Alleles; Animal Anatomy; Animal Biochemistry; Arabs - genetics; Bahrain; Biomedical and Life Sciences; Case-Control Studies; Female; Gene Frequency; Genetic markers; Genetic Predisposition to Disease; Genotype; Genotype & phenotype; Histology; Humans; Janus Kinase 2 - genetics; Life Sciences; Miscarriage; Morphology; Odds Ratio; Polymorphism; Polymorphism, Genetic; Polymorphism, Single Nucleotide; Pregnancy; Risk factors; STAT3 Transcription Factor - genetics; Tunisia
• ISSN: 0301-4851; 1573-4978
• DOI: 10.1007/s11033-012-2096-8

We investigated the contribution of JAK2 rs2203724 and STAT3 rs1053023 and rs1053004 to the susceptibility of idiopathic recurrent miscarriage (IRM) in Bahraini (246 cases and 279 controls) and Tunisian (235 cases and 235 controls) Arabs. The distribution of JAK2 rs2203724 and STAT3 rs1053023 genotypes were in Hardy–Weinberg equilibrium (HWE) in both communities, while mild deviation from HWE was noted for rs1053004 in Tunisians but not Bahraini. JAK2 rs2203724 was not associated with IRM in either community, while STAT3 rs1053023 was positively associated with IRM in both Bahraini and Tunisian women. STAT3 rs1053004 displayed mixed association: it was positively associated with IRM in Bahraini ( P