Loading…
Language lateralization by fMRI and Wada testing in 229 patients with epilepsy: Rates and predictors of discordance
Summary Purpose To more definitively characterize Wada/functional magnetic resonance imaging (fMRI) language dominance discordance rates with the largest sample of patients with epilepsy to date, and to examine demographic, clinical, and methodologic predictors of discordance. Methods Two hundred tw...
Saved in:
Published in: | Epilepsia (Copenhagen) 2013-02, Vol.54 (2), p.314-322 |
---|---|
Main Authors: | , , , , , , |
Format: | Article |
Language: | English |
Subjects: | |
Online Access: | Get full text |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
cited_by | |
---|---|
cites | |
container_end_page | 322 |
container_issue | 2 |
container_start_page | 314 |
container_title | Epilepsia (Copenhagen) |
container_volume | 54 |
creator | Janecek, Julie K. Swanson, Sara J. Sabsevitz, David S. Hammeke, Thomas A. Raghavan, Manoj E. Rozman, Megan Binder, Jeffrey R. |
description | Summary
Purpose
To more definitively characterize Wada/functional magnetic resonance imaging (fMRI) language dominance discordance rates with the largest sample of patients with epilepsy to date, and to examine demographic, clinical, and methodologic predictors of discordance.
Methods
Two hundred twenty‐nine patients with epilepsy underwent both a standardized Wada test and a semantic decision fMRI language protocol in a prospective research study. Language laterality indices were computed for each test using automated and double‐blind methods, and Wada/fMRI discordance rates were calculated using objective criteria for discordance. Regression analyses were used to explore a range of variables that might predict discordance, including subject variables, Wada quality indices, and fMRI quality indices.
Key Findings
Discordant results were observed in 14% of patients. Discordance was highest among those categorized by either test as having bilateral language. In a multivariate model, the only factor that predicted discordance was the degree of atypical language dominance on fMRI.
Significance
fMRI language lateralization is generally concordant with Wada testing. The degree of rightward shift of language dominance on fMRI testing is strongly correlated with Wada/fMRI discordance, suggesting that fMRI may be more sensitive than Wada to right hemisphere language processing, although the clinical significance of this increased sensitivity is unknown. The relative accuracy of fMRI versus Wada testing for predicting postsurgical language outcome in discordant cases remains a topic for future research. |
doi_str_mv | 10.1111/epi.12068 |
format | article |
fullrecord | <record><control><sourceid>proquest_pubme</sourceid><recordid>TN_cdi_proquest_miscellaneous_1315610471</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1315610471</sourcerecordid><originalsourceid>FETCH-LOGICAL-p3478-f7664cb2f4102f231100cb487ae0eb9c5ef56686dee30860ab64e7194ec891ec3</originalsourceid><addsrcrecordid>eNqFkU9r3DAQxUVJaTZpD_0CRZBLLk5mJFmWeytL_ixsSVhaejSyPd4oeGXXsgnbTx_tbpJDLh0EM6CfHk9vGPuKcIGxLql3FyhAmw9shqkwCaLOjtgMAGWSpwaO2UkIjwCQ6Ux-YsdCilyhFjMWltavJ7sm3tqRBtu6f3Z0neflljc_Vwtufc3_2NrykcLo_Jo7z4XIeR8x8mPgT2584NFBS33YfuerKBP2r_qBaleN3RB41_Dahaobausr-sw-NrYN9OWln7Lf11e_5rfJ8u5mMf-xTHqpMpM0mdaqKkWjEEQjJCJAVSqTWQIq8yqlJtXa6JpIgtFgS60ow1xRZXKkSp6y84NuP3R_p2i_2EQT1LbWUzeFAiWmGkFl-H9UmBSMiCeiZ-_Qx24afPzIjlKQK6F21LcXaio3VBf94DZ22BavyUfg8gA8xeS2b_cIxW6lRQy02K-0uLpf7Af5DDDqkY8</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1284094242</pqid></control><display><type>article</type><title>Language lateralization by fMRI and Wada testing in 229 patients with epilepsy: Rates and predictors of discordance</title><source>Wiley</source><creator>Janecek, Julie K. ; Swanson, Sara J. ; Sabsevitz, David S. ; Hammeke, Thomas A. ; Raghavan, Manoj ; E. Rozman, Megan ; Binder, Jeffrey R.</creator><creatorcontrib>Janecek, Julie K. ; Swanson, Sara J. ; Sabsevitz, David S. ; Hammeke, Thomas A. ; Raghavan, Manoj ; E. Rozman, Megan ; Binder, Jeffrey R.</creatorcontrib><description>Summary
Purpose
To more definitively characterize Wada/functional magnetic resonance imaging (fMRI) language dominance discordance rates with the largest sample of patients with epilepsy to date, and to examine demographic, clinical, and methodologic predictors of discordance.
Methods
Two hundred twenty‐nine patients with epilepsy underwent both a standardized Wada test and a semantic decision fMRI language protocol in a prospective research study. Language laterality indices were computed for each test using automated and double‐blind methods, and Wada/fMRI discordance rates were calculated using objective criteria for discordance. Regression analyses were used to explore a range of variables that might predict discordance, including subject variables, Wada quality indices, and fMRI quality indices.
Key Findings
Discordant results were observed in 14% of patients. Discordance was highest among those categorized by either test as having bilateral language. In a multivariate model, the only factor that predicted discordance was the degree of atypical language dominance on fMRI.
Significance
fMRI language lateralization is generally concordant with Wada testing. The degree of rightward shift of language dominance on fMRI testing is strongly correlated with Wada/fMRI discordance, suggesting that fMRI may be more sensitive than Wada to right hemisphere language processing, although the clinical significance of this increased sensitivity is unknown. The relative accuracy of fMRI versus Wada testing for predicting postsurgical language outcome in discordant cases remains a topic for future research.</description><identifier>ISSN: 0013-9580</identifier><identifier>EISSN: 1528-1167</identifier><identifier>DOI: 10.1111/epi.12068</identifier><identifier>PMID: 23294162</identifier><identifier>CODEN: EPILAK</identifier><language>eng</language><publisher>United States: Wiley Subscription Services, Inc</publisher><subject>Adult ; Age of Onset ; Amobarbital ; Brain ; Clinical trials ; Electroencephalography ; Epilepsy ; Epilepsy - diagnosis ; Epilepsy - physiopathology ; Female ; fMRI ; Functional Laterality - physiology ; Humans ; Hypnotics and Sedatives ; Image Processing, Computer-Assisted ; Language ; Language lateralization ; Magnetic Resonance Imaging ; Male ; Predictive Value of Tests ; Prospective Studies ; Wada</subject><ispartof>Epilepsia (Copenhagen), 2013-02, Vol.54 (2), p.314-322</ispartof><rights>Wiley Periodicals, Inc. © 2013 International League Against Epilepsy</rights><rights>Wiley Periodicals, Inc. © 2013 International League Against Epilepsy.</rights><rights>Copyright © 2013 International League Against Epilepsy</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23294162$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Janecek, Julie K.</creatorcontrib><creatorcontrib>Swanson, Sara J.</creatorcontrib><creatorcontrib>Sabsevitz, David S.</creatorcontrib><creatorcontrib>Hammeke, Thomas A.</creatorcontrib><creatorcontrib>Raghavan, Manoj</creatorcontrib><creatorcontrib>E. Rozman, Megan</creatorcontrib><creatorcontrib>Binder, Jeffrey R.</creatorcontrib><title>Language lateralization by fMRI and Wada testing in 229 patients with epilepsy: Rates and predictors of discordance</title><title>Epilepsia (Copenhagen)</title><addtitle>Epilepsia</addtitle><description>Summary
Purpose
To more definitively characterize Wada/functional magnetic resonance imaging (fMRI) language dominance discordance rates with the largest sample of patients with epilepsy to date, and to examine demographic, clinical, and methodologic predictors of discordance.
Methods
Two hundred twenty‐nine patients with epilepsy underwent both a standardized Wada test and a semantic decision fMRI language protocol in a prospective research study. Language laterality indices were computed for each test using automated and double‐blind methods, and Wada/fMRI discordance rates were calculated using objective criteria for discordance. Regression analyses were used to explore a range of variables that might predict discordance, including subject variables, Wada quality indices, and fMRI quality indices.
Key Findings
Discordant results were observed in 14% of patients. Discordance was highest among those categorized by either test as having bilateral language. In a multivariate model, the only factor that predicted discordance was the degree of atypical language dominance on fMRI.
Significance
fMRI language lateralization is generally concordant with Wada testing. The degree of rightward shift of language dominance on fMRI testing is strongly correlated with Wada/fMRI discordance, suggesting that fMRI may be more sensitive than Wada to right hemisphere language processing, although the clinical significance of this increased sensitivity is unknown. The relative accuracy of fMRI versus Wada testing for predicting postsurgical language outcome in discordant cases remains a topic for future research.</description><subject>Adult</subject><subject>Age of Onset</subject><subject>Amobarbital</subject><subject>Brain</subject><subject>Clinical trials</subject><subject>Electroencephalography</subject><subject>Epilepsy</subject><subject>Epilepsy - diagnosis</subject><subject>Epilepsy - physiopathology</subject><subject>Female</subject><subject>fMRI</subject><subject>Functional Laterality - physiology</subject><subject>Humans</subject><subject>Hypnotics and Sedatives</subject><subject>Image Processing, Computer-Assisted</subject><subject>Language</subject><subject>Language lateralization</subject><subject>Magnetic Resonance Imaging</subject><subject>Male</subject><subject>Predictive Value of Tests</subject><subject>Prospective Studies</subject><subject>Wada</subject><issn>0013-9580</issn><issn>1528-1167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkU9r3DAQxUVJaTZpD_0CRZBLLk5mJFmWeytL_ixsSVhaejSyPd4oeGXXsgnbTx_tbpJDLh0EM6CfHk9vGPuKcIGxLql3FyhAmw9shqkwCaLOjtgMAGWSpwaO2UkIjwCQ6Ux-YsdCilyhFjMWltavJ7sm3tqRBtu6f3Z0neflljc_Vwtufc3_2NrykcLo_Jo7z4XIeR8x8mPgT2584NFBS33YfuerKBP2r_qBaleN3RB41_Dahaobausr-sw-NrYN9OWln7Lf11e_5rfJ8u5mMf-xTHqpMpM0mdaqKkWjEEQjJCJAVSqTWQIq8yqlJtXa6JpIgtFgS60ow1xRZXKkSp6y84NuP3R_p2i_2EQT1LbWUzeFAiWmGkFl-H9UmBSMiCeiZ-_Qx24afPzIjlKQK6F21LcXaio3VBf94DZ22BavyUfg8gA8xeS2b_cIxW6lRQy02K-0uLpf7Af5DDDqkY8</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>Janecek, Julie K.</creator><creator>Swanson, Sara J.</creator><creator>Sabsevitz, David S.</creator><creator>Hammeke, Thomas A.</creator><creator>Raghavan, Manoj</creator><creator>E. Rozman, Megan</creator><creator>Binder, Jeffrey R.</creator><general>Wiley Subscription Services, Inc</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>7TK</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Language lateralization by fMRI and Wada testing in 229 patients with epilepsy: Rates and predictors of discordance</title><author>Janecek, Julie K. ; Swanson, Sara J. ; Sabsevitz, David S. ; Hammeke, Thomas A. ; Raghavan, Manoj ; E. Rozman, Megan ; Binder, Jeffrey R.</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-p3478-f7664cb2f4102f231100cb487ae0eb9c5ef56686dee30860ab64e7194ec891ec3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adult</topic><topic>Age of Onset</topic><topic>Amobarbital</topic><topic>Brain</topic><topic>Clinical trials</topic><topic>Electroencephalography</topic><topic>Epilepsy</topic><topic>Epilepsy - diagnosis</topic><topic>Epilepsy - physiopathology</topic><topic>Female</topic><topic>fMRI</topic><topic>Functional Laterality - physiology</topic><topic>Humans</topic><topic>Hypnotics and Sedatives</topic><topic>Image Processing, Computer-Assisted</topic><topic>Language</topic><topic>Language lateralization</topic><topic>Magnetic Resonance Imaging</topic><topic>Male</topic><topic>Predictive Value of Tests</topic><topic>Prospective Studies</topic><topic>Wada</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Janecek, Julie K.</creatorcontrib><creatorcontrib>Swanson, Sara J.</creatorcontrib><creatorcontrib>Sabsevitz, David S.</creatorcontrib><creatorcontrib>Hammeke, Thomas A.</creatorcontrib><creatorcontrib>Raghavan, Manoj</creatorcontrib><creatorcontrib>E. Rozman, Megan</creatorcontrib><creatorcontrib>Binder, Jeffrey R.</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>Neurosciences Abstracts</collection><collection>MEDLINE - Academic</collection><jtitle>Epilepsia (Copenhagen)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Janecek, Julie K.</au><au>Swanson, Sara J.</au><au>Sabsevitz, David S.</au><au>Hammeke, Thomas A.</au><au>Raghavan, Manoj</au><au>E. Rozman, Megan</au><au>Binder, Jeffrey R.</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Language lateralization by fMRI and Wada testing in 229 patients with epilepsy: Rates and predictors of discordance</atitle><jtitle>Epilepsia (Copenhagen)</jtitle><addtitle>Epilepsia</addtitle><date>2013-02</date><risdate>2013</risdate><volume>54</volume><issue>2</issue><spage>314</spage><epage>322</epage><pages>314-322</pages><issn>0013-9580</issn><eissn>1528-1167</eissn><coden>EPILAK</coden><abstract>Summary
Purpose
To more definitively characterize Wada/functional magnetic resonance imaging (fMRI) language dominance discordance rates with the largest sample of patients with epilepsy to date, and to examine demographic, clinical, and methodologic predictors of discordance.
Methods
Two hundred twenty‐nine patients with epilepsy underwent both a standardized Wada test and a semantic decision fMRI language protocol in a prospective research study. Language laterality indices were computed for each test using automated and double‐blind methods, and Wada/fMRI discordance rates were calculated using objective criteria for discordance. Regression analyses were used to explore a range of variables that might predict discordance, including subject variables, Wada quality indices, and fMRI quality indices.
Key Findings
Discordant results were observed in 14% of patients. Discordance was highest among those categorized by either test as having bilateral language. In a multivariate model, the only factor that predicted discordance was the degree of atypical language dominance on fMRI.
Significance
fMRI language lateralization is generally concordant with Wada testing. The degree of rightward shift of language dominance on fMRI testing is strongly correlated with Wada/fMRI discordance, suggesting that fMRI may be more sensitive than Wada to right hemisphere language processing, although the clinical significance of this increased sensitivity is unknown. The relative accuracy of fMRI versus Wada testing for predicting postsurgical language outcome in discordant cases remains a topic for future research.</abstract><cop>United States</cop><pub>Wiley Subscription Services, Inc</pub><pmid>23294162</pmid><doi>10.1111/epi.12068</doi><tpages>9</tpages><oa>free_for_read</oa></addata></record> |
fulltext | fulltext |
identifier | ISSN: 0013-9580 |
ispartof | Epilepsia (Copenhagen), 2013-02, Vol.54 (2), p.314-322 |
issn | 0013-9580 1528-1167 |
language | eng |
recordid | cdi_proquest_miscellaneous_1315610471 |
source | Wiley |
subjects | Adult Age of Onset Amobarbital Brain Clinical trials Electroencephalography Epilepsy Epilepsy - diagnosis Epilepsy - physiopathology Female fMRI Functional Laterality - physiology Humans Hypnotics and Sedatives Image Processing, Computer-Assisted Language Language lateralization Magnetic Resonance Imaging Male Predictive Value of Tests Prospective Studies Wada |
title | Language lateralization by fMRI and Wada testing in 229 patients with epilepsy: Rates and predictors of discordance |
url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2024-12-25T15%3A49%3A54IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_pubme&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Language%20lateralization%20by%20fMRI%20and%20Wada%20testing%20in%20229%20patients%20with%20epilepsy:%20Rates%20and%20predictors%20of%20discordance&rft.jtitle=Epilepsia%20(Copenhagen)&rft.au=Janecek,%20Julie%20K.&rft.date=2013-02&rft.volume=54&rft.issue=2&rft.spage=314&rft.epage=322&rft.pages=314-322&rft.issn=0013-9580&rft.eissn=1528-1167&rft.coden=EPILAK&rft_id=info:doi/10.1111/epi.12068&rft_dat=%3Cproquest_pubme%3E1315610471%3C/proquest_pubme%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-p3478-f7664cb2f4102f231100cb487ae0eb9c5ef56686dee30860ab64e7194ec891ec3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1284094242&rft_id=info:pmid/23294162&rfr_iscdi=true |