Genetic structure of Aspergillus flavus populations in human and avian isolates

Aspergillus flavus is the second leading cause of allergic, invasive, and colonizing fungal diseases in humans, and also the second most frequent organism associated with avian infections. Currently, it is not known whether there is a link between the environmental isolates and/or human isolates of...

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Bibliographic Details
Published in:European journal of clinical microbiology & infectious diseases 2013-02, Vol.32 (2), p.277-282
Main Authors: Hadrich, I., Amouri, I., Neji, S., Mahfoud, N., Ranque, S., Makni, F., Ayadi, A.
Format: Article
Language:English
Subjects:
Animal populations
Animals
Aspergillosis
Aspergillosis - microbiology
Aspergillosis - veterinary
Aspergillus flavus
Aspergillus flavus - classification
Aspergillus flavus - genetics
Aspergillus flavus - isolation & purification
Biological and medical sciences
Biomedical and Life Sciences
Biomedicine
Bird populations
Birds
Cluster Analysis
Environmental Microbiology
Epidemiology
Genetic diversity
Genetic structure
Genetic Variation
Genotype
Genotype & phenotype
Genotypes
Humans
Infections
Infectious diseases
Internal Medicine
Medical Microbiology
Medical sciences
Microsatellite Repeats
Molecular Typing
Mycological Typing Techniques
Pathogens
Poultry
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Summary:Aspergillus flavus is the second leading cause of allergic, invasive, and colonizing fungal diseases in humans, and also the second most frequent organism associated with avian infections. Currently, it is not known whether there is a link between the environmental isolates and/or human isolates of A. flavus and those responsible for aspergillosis in birds. Microsatellite typing was used to analyze 29 A. flavus clinical and environmental avian isolates and 63 human clinical isolates collected from patients with a variety of aspergillosis diseases. The combination of all six markers yielded 77 different genotypes with a 0.98 D value. A. flavus genotypes obtained from avian isolates were compared with those obtained from human clinical and environmental samples. The standardized indices of association I A and rBarD were significantly different from zero ( p   0.25). The avian clinical subpopulation exchanged few strains with the environmental human ( N m  = 7.24) and avian ( N m  = 6.60) populations. The minimum spanning tree analysis identified three A. flavus genotype clusters that were highly structured according to the isolation source ( p  
ISSN:0934-9723
1435-4373
DOI:10.1007/s10096-012-1740-5