Downregulation of CCR5 Expression on the Peripheral Blood CD8 super(+) T Cells of Southeastern Iranian Patients with Chronic Hepatitis B Infection

Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the...

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Bibliographic Details
Published in:Inflammation 2013-02, Vol.36 (1), p.136-140
Main Authors: Ahmadabadi, Behzad Nasiri, Hassanshahi, Gholamhossein, Khoramdelazad, Hossein, Mirzaei, Vahid, Sajadi, Seyed Mohammad Ali, Hajghani, Masomeh, Khodadadi, Hassan, Pourali, Reza, Arababadi, Mohammad Kazemi, Kennedy, Derek
Format: Article
Language:English
Subjects:
CCL4 protein
CCR5 protein
CD8 antigen
Chronic infection
Cytotoxicity
Flow cytometry
Hepatitis B
Hepatitis B virus
Hepatocytes
Leukocyte migration
Liver
Lymphocytes T
Peripheral blood
Polymerase chain reaction
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Summary:Studies indicated that CC receptor 5 (CCR5), as a receptor for CC ligand 3, CCL4, and CCL5, plays important roles in the recruitment of T cytotoxic lymphocytes to the liver of chronic HBV (CHB)-infected patients. The main purpose of this study was to investigate the expression levels of CCR5 on the CD8 super(+) T lymphocytes of CHB patients. This clinical study was performed on 63 CHB patients and 96 healthy controls. Flow cytometric analysis was performed to examine the expression of CCR5 on CD8 super(+) T cells of CHB patients. Real-time PCR was also used for HBV-DNA quantification. The results of our study demonstrated that CCR5 expressing T cytotoxic cells were decreased significantly in CHB patients in comparison to healthy control. Based on our results, it can be concluded that the percent of CCR5 super(+)/CD8 super(+) T cells in Iranian CHB patients is significantly decreased, hence their migration to the infected liver, and HBV eradication from the hepatocytes is disrupted.
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-012-9528-4