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Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems
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| Published in: | Antimicrobial Agents and Chemotherapy 2013-02, Vol.57 (2), p.723-733 |
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| container_end_page | 733 |
| container_issue | 2 |
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| container_title | Antimicrobial Agents and Chemotherapy |
| container_volume | 57 |
| creator | LIN, Hui-Mei WANG, Jing-Chyi CHAO, Yu-Sheng CHERN, Jyh-Haur YUEH, Andrew HU, Han-Shu WU, Pei-Shan WANG, Wen-Hung WU, Su-Ying YANG, Chi-Chen YEH, Teng-Kuang HSU, Tsu-An JIAANG, Weir-Torn |
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| doi_str_mv | 10.1128/AAC.01403-12 |
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</description><identifier>ISSN: 0066-4804</identifier><identifier>EISSN: 1098-6596</identifier><identifier>DOI: 10.1128/AAC.01403-12</identifier><identifier>PMID: 23165461</identifier><identifier>CODEN: AACHAX</identifier><language>eng</language><publisher>Washington, DC: American Society for Microbiology</publisher><subject>alpha -Interferon ; Amino Acid Substitution ; Antibiotics. Antiinfectious agents. Antiparasitic agents ; Antiviral Agents ; Antiviral Agents - chemistry ; Antiviral Agents - pharmacology ; Biological and medical sciences ; Cell Line, Tumor ; Chronic infection ; Disease resistance ; Drug resistance ; Drug Resistance, Viral ; Drug Resistance, Viral - genetics ; Flaviviridae ; Genotype ; Genotypes ; Hepacivirus - drug effects ; Hepacivirus - genetics ; Hepatitis C virus ; Hepatitis C, Chronic ; Hepatitis C, Chronic - drug therapy ; Hepatitis C, Chronic - virology ; Human viral diseases ; Humans ; Infectious diseases ; Interferon-alpha - pharmacology ; Liver diseases ; Medical sciences ; Mutation ; Pharmacology. Drug treatments ; Protein Binding ; Proteinase inhibitors ; Pyrrolidines ; Pyrrolidines - pharmacology ; Replication ; Replicon ; RNA, Viral - analysis ; RNA-directed RNA polymerase ; Sequence Analysis, RNA ; Thiazoles ; Thiazoles - pharmacology ; Viral diseases ; Viral hepatitis ; Viral Nonstructural Proteins ; Viral Nonstructural Proteins - antagonists & inhibitors ; Viral Nonstructural Proteins - chemistry ; Viral Nonstructural Proteins - genetics</subject><ispartof>Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.723-733</ispartof><rights>2014 INIST-CNRS</rights><rights>Copyright © 2013, American Society for Microbiology. All Rights Reserved.</rights><rights>Copyright © 2013, American Society for Microbiology. All Rights Reserved. 2013 American Society for Microbiology</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-a506t-54e05dbf7013f92b6385285caf8c35deb39c1c011362ecbbddec6355885ca8823</citedby><cites>FETCH-LOGICAL-a506t-54e05dbf7013f92b6385285caf8c35deb39c1c011362ecbbddec6355885ca8823</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktopdf>$$Uhttps://journals.asm.org/doi/pdf/10.1128/AAC.01403-12$$EPDF$$P50$$Gasm2$$H</linktopdf><linktohtml>$$Uhttps://journals.asm.org/doi/full/10.1128/AAC.01403-12$$EHTML$$P50$$Gasm2$$H</linktohtml><link.rule.ids>230,314,723,776,780,881,3174,3175,27903,27904,52729,52730,52731,53769,53771</link.rule.ids><backlink>$$Uhttp://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=26906966$$DView record in Pascal Francis$$Hfree_for_read</backlink><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23165461$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>LIN, Hui-Mei</creatorcontrib><creatorcontrib>WANG, Jing-Chyi</creatorcontrib><creatorcontrib>CHAO, Yu-Sheng</creatorcontrib><creatorcontrib>CHERN, Jyh-Haur</creatorcontrib><creatorcontrib>YUEH, Andrew</creatorcontrib><creatorcontrib>HU, Han-Shu</creatorcontrib><creatorcontrib>WU, Pei-Shan</creatorcontrib><creatorcontrib>WANG, Wen-Hung</creatorcontrib><creatorcontrib>WU, Su-Ying</creatorcontrib><creatorcontrib>YANG, Chi-Chen</creatorcontrib><creatorcontrib>YEH, Teng-Kuang</creatorcontrib><creatorcontrib>HSU, Tsu-An</creatorcontrib><creatorcontrib>JIAANG, Weir-Torn</creatorcontrib><title>Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems</title><title>Antimicrobial Agents and Chemotherapy</title><addtitle>Antimicrob Agents Chemother</addtitle><addtitle>Antimicrob Agents Chemother</addtitle><description>Classifications
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</description><subject>alpha -Interferon</subject><subject>Amino Acid Substitution</subject><subject>Antibiotics. Antiinfectious agents. Antiparasitic agents</subject><subject>Antiviral Agents</subject><subject>Antiviral Agents - chemistry</subject><subject>Antiviral Agents - pharmacology</subject><subject>Biological and medical sciences</subject><subject>Cell Line, Tumor</subject><subject>Chronic infection</subject><subject>Disease resistance</subject><subject>Drug resistance</subject><subject>Drug Resistance, Viral</subject><subject>Drug Resistance, Viral - genetics</subject><subject>Flaviviridae</subject><subject>Genotype</subject><subject>Genotypes</subject><subject>Hepacivirus - drug effects</subject><subject>Hepacivirus - genetics</subject><subject>Hepatitis C virus</subject><subject>Hepatitis C, Chronic</subject><subject>Hepatitis C, Chronic - drug therapy</subject><subject>Hepatitis C, Chronic - virology</subject><subject>Human viral diseases</subject><subject>Humans</subject><subject>Infectious diseases</subject><subject>Interferon-alpha - pharmacology</subject><subject>Liver diseases</subject><subject>Medical sciences</subject><subject>Mutation</subject><subject>Pharmacology. 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Antiinfectious agents. Antiparasitic agents</topic><topic>Antiviral Agents</topic><topic>Antiviral Agents - chemistry</topic><topic>Antiviral Agents - pharmacology</topic><topic>Biological and medical sciences</topic><topic>Cell Line, Tumor</topic><topic>Chronic infection</topic><topic>Disease resistance</topic><topic>Drug resistance</topic><topic>Drug Resistance, Viral</topic><topic>Drug Resistance, Viral - genetics</topic><topic>Flaviviridae</topic><topic>Genotype</topic><topic>Genotypes</topic><topic>Hepacivirus - drug effects</topic><topic>Hepacivirus - genetics</topic><topic>Hepatitis C virus</topic><topic>Hepatitis C, Chronic</topic><topic>Hepatitis C, Chronic - drug therapy</topic><topic>Hepatitis C, Chronic - virology</topic><topic>Human viral diseases</topic><topic>Humans</topic><topic>Infectious diseases</topic><topic>Interferon-alpha - pharmacology</topic><topic>Liver diseases</topic><topic>Medical sciences</topic><topic>Mutation</topic><topic>Pharmacology. Drug treatments</topic><topic>Protein Binding</topic><topic>Proteinase inhibitors</topic><topic>Pyrrolidines</topic><topic>Pyrrolidines - pharmacology</topic><topic>Replication</topic><topic>Replicon</topic><topic>RNA, Viral - analysis</topic><topic>RNA-directed RNA polymerase</topic><topic>Sequence Analysis, RNA</topic><topic>Thiazoles</topic><topic>Thiazoles - pharmacology</topic><topic>Viral diseases</topic><topic>Viral hepatitis</topic><topic>Viral Nonstructural Proteins</topic><topic>Viral Nonstructural Proteins - antagonists & inhibitors</topic><topic>Viral Nonstructural Proteins - chemistry</topic><topic>Viral Nonstructural Proteins - genetics</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>LIN, Hui-Mei</creatorcontrib><creatorcontrib>WANG, Jing-Chyi</creatorcontrib><creatorcontrib>CHAO, Yu-Sheng</creatorcontrib><creatorcontrib>CHERN, Jyh-Haur</creatorcontrib><creatorcontrib>YUEH, Andrew</creatorcontrib><creatorcontrib>HU, Han-Shu</creatorcontrib><creatorcontrib>WU, Pei-Shan</creatorcontrib><creatorcontrib>WANG, Wen-Hung</creatorcontrib><creatorcontrib>WU, Su-Ying</creatorcontrib><creatorcontrib>YANG, Chi-Chen</creatorcontrib><creatorcontrib>YEH, Teng-Kuang</creatorcontrib><creatorcontrib>HSU, Tsu-An</creatorcontrib><creatorcontrib>JIAANG, Weir-Torn</creatorcontrib><collection>Pascal-Francis</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Industrial and Applied Microbiology Abstracts (Microbiology A)</collection><collection>Virology and AIDS Abstracts</collection><collection>Technology Research Database</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Engineering Research Database</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>Biotechnology and BioEngineering Abstracts</collection><collection>PubMed Central (Full Participant titles)</collection><jtitle>Antimicrobial Agents and Chemotherapy</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>LIN, Hui-Mei</au><au>WANG, Jing-Chyi</au><au>CHAO, Yu-Sheng</au><au>CHERN, Jyh-Haur</au><au>YUEH, Andrew</au><au>HU, Han-Shu</au><au>WU, Pei-Shan</au><au>WANG, Wen-Hung</au><au>WU, Su-Ying</au><au>YANG, Chi-Chen</au><au>YEH, Teng-Kuang</au><au>HSU, Tsu-An</au><au>JIAANG, Weir-Torn</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems</atitle><jtitle>Antimicrobial Agents and Chemotherapy</jtitle><stitle>Antimicrob Agents Chemother</stitle><addtitle>Antimicrob Agents Chemother</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>57</volume><issue>2</issue><spage>723</spage><epage>733</epage><pages>723-733</pages><issn>0066-4804</issn><eissn>1098-6596</eissn><coden>AACHAX</coden><abstract>Classifications
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</abstract><cop>Washington, DC</cop><pub>American Society for Microbiology</pub><pmid>23165461</pmid><doi>10.1128/AAC.01403-12</doi><tpages>11</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0066-4804 |
| ispartof | Antimicrobial Agents and Chemotherapy, 2013-02, Vol.57 (2), p.723-733 |
| issn | 0066-4804 1098-6596 |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1315617436 |
| source | PubMed Central(OpenAccess); American Society for Microbiology Journals |
| subjects | alpha -Interferon Amino Acid Substitution Antibiotics. Antiinfectious agents. Antiparasitic agents Antiviral Agents Antiviral Agents - chemistry Antiviral Agents - pharmacology Biological and medical sciences Cell Line, Tumor Chronic infection Disease resistance Drug resistance Drug Resistance, Viral Drug Resistance, Viral - genetics Flaviviridae Genotype Genotypes Hepacivirus - drug effects Hepacivirus - genetics Hepatitis C virus Hepatitis C, Chronic Hepatitis C, Chronic - drug therapy Hepatitis C, Chronic - virology Human viral diseases Humans Infectious diseases Interferon-alpha - pharmacology Liver diseases Medical sciences Mutation Pharmacology. Drug treatments Protein Binding Proteinase inhibitors Pyrrolidines Pyrrolidines - pharmacology Replication Replicon RNA, Viral - analysis RNA-directed RNA polymerase Sequence Analysis, RNA Thiazoles Thiazoles - pharmacology Viral diseases Viral hepatitis Viral Nonstructural Proteins Viral Nonstructural Proteins - antagonists & inhibitors Viral Nonstructural Proteins - chemistry Viral Nonstructural Proteins - genetics |
| title | Resistance Studies of a Dithiazol Analogue, DBPR110, as a Potential Hepatitis C Virus NS5A Inhibitor in Replicon Systems |
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