Facial Affect Recognition in CADASIL Patients

We explored the capacity of Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients to recognize facial expressions. Twenty-three consecutive CADASIL patients and 23 age-matched, gender-matched, and education-matched controls were assessed with a...

Full description

Saved in:
Bibliographic Details
Published in:Archives of clinical neuropsychology 2013-02, Vol.28 (1), p.65-71
Main Authors: VALENTI, Raffaella, SALVADORI, Emilia, PESCINI, Francesca, POGGESI, Anna, CASTELLINI, Giovanni, ANTONINI, Sarah, BIANCHI, Silvia, INZITARI, Domenico, PALLANTI, Stefano, PANTONI, Leonardo
Format: Article
Language:English
Subjects:
Adult
Adult and adolescent clinical studies
Aged
Analysis of Variance
Biological and medical sciences
CADASIL - complications
Case-Control Studies
Cognitive ability
Cognitive Dysfunction - diagnosis
Cognitive Dysfunction - etiology
Depression
Emotions
Facial Expression
Fear
Female
Humans
Leukoencephalopathy
Male
Medical sciences
Middle Aged
Mood disorders
Neuropsychological Tests
Organic mental disorders. Neuropsychology
Pattern recognition
Photic Stimulation
Psychology. Psychoanalysis. Psychiatry
Psychopathology. Psychiatry
Recognition (Psychology) - physiology
Regression Analysis
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:We explored the capacity of Cerebral Autosomal-Dominant Arteriopathy with Subcortical Infarcts and Leukoencephalopathy (CADASIL) patients to recognize facial expressions. Twenty-three consecutive CADASIL patients and 23 age-matched, gender-matched, and education-matched controls were assessed with a semi-structured psychiatric interview, cognitive tests, and the Ekman and Friesen test. Cases and controls (5 males, 18 females) had a mean age (+SD) of 52.4 + 15.7 and 54.0 + 15.3 years, respectively, and a Mini-Mental State Examination (MMSE) mean score of 27.8 + 2.2 and 28.9 + 1.3 (p < .05). Eighteen out of the 23 (78.3%) CADASIL patients and 10 (43.5%) controls were diagnosed as affected by major depression according to DSM-IV criteria (p < .05). The CADASIL patients had an impaired ability of emotion recognition in comparison with controls, particularly for fear expression. This effect was not mediated by depression, cognitive impairment, and MMSE score. Facial affect recognition is reduced in the CADASIL patients and this impairment might represent an early manifestation of the disease.
ISSN:0887-6177
1873-5843
DOI:10.1093/arclin/acs097