Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity

► Central obesity promotes the secretion of pro-inflammatory TNF-α, IL-1β, leptin. ► Anti-inflammatory IL-4, IL-5 cytokines increase and adiponectin decreases. ► This pointed to the importance of leptin/Adiponectin balance. ► The positive correlation between IL-4, IL-5. ► Points to a possible correl...

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Bibliographic Details
Published in:Cytokine (Philadelphia, Pa.) Pa.), 2013-02, Vol.61 (2), p.682-687
Main Authors: El-Wakkad, Amany, Hassan, Nayera El-Morsi, Sibaii, Hiba, El-Zayat, Salwa Refat
Format: Article
Language:English
Subjects:
Adipokines
Adiponectin
Adiponectin - blood
Adolescence
Adolescent
Adolescent girls
adolescents
Anti-Inflammatory Agents - blood
Anti-inflammatory cytokines
Asthma
Central obesity
Cytokines - blood
Female
girls
Hip
Humans
Inflammation
Inflammation Mediators - blood
Interleukin 4
Interleukin 5
Interleukin-1beta - blood
Interleukin-4 - blood
Interleukin-5 - blood
Leptin
Leptin - blood
Obesity
Obesity, Abdominal - blood
Plasma levels
Proinflammatory
Students
Tumor necrosis factor- alpha
Waist-Hip Ratio
waist-to-hip ratio
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Summary:► Central obesity promotes the secretion of pro-inflammatory TNF-α, IL-1β, leptin. ► Anti-inflammatory IL-4, IL-5 cytokines increase and adiponectin decreases. ► This pointed to the importance of leptin/Adiponectin balance. ► The positive correlation between IL-4, IL-5. ► Points to a possible correlation between central obesity and allergic conditions. Several studies have investigated the correlation between central obesity and inflammatory cytokines and the anti-inflammatory cytokine adiponectin. But, the correlation between central obesity and the anti-inflammatory cytokines IL-4, IL-5 has not been studied yet. Thus, we aimed to study the IL-4 and IL-5 correlation to central obesity in adolescent Egyptian girls among proinflammatory and anti-inflammatory cytokines. The study was carried out on 86 obese adolescent girls (BMI>95 percentile) divided into two groups according to central obesity. The group I with waist to hip ratio 0.8 (central obesity). There was a significant increase in TNF-alpha (p
ISSN:1043-4666
1096-0023
DOI:10.1016/j.cyto.2012.11.010