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Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity
► Central obesity promotes the secretion of pro-inflammatory TNF-α, IL-1β, leptin. ► Anti-inflammatory IL-4, IL-5 cytokines increase and adiponectin decreases. ► This pointed to the importance of leptin/Adiponectin balance. ► The positive correlation between IL-4, IL-5. ► Points to a possible correl...
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| Published in: | Cytokine (Philadelphia, Pa.) Pa.), 2013-02, Vol.61 (2), p.682-687 |
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| container_end_page | 687 |
| container_issue | 2 |
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| container_title | Cytokine (Philadelphia, Pa.) |
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| creator | El-Wakkad, Amany Hassan, Nayera El-Morsi Sibaii, Hiba El-Zayat, Salwa Refat |
| description | ► Central obesity promotes the secretion of pro-inflammatory TNF-α, IL-1β, leptin. ► Anti-inflammatory IL-4, IL-5 cytokines increase and adiponectin decreases. ► This pointed to the importance of leptin/Adiponectin balance. ► The positive correlation between IL-4, IL-5. ► Points to a possible correlation between central obesity and allergic conditions.
Several studies have investigated the correlation between central obesity and inflammatory cytokines and the anti-inflammatory cytokine adiponectin. But, the correlation between central obesity and the anti-inflammatory cytokines IL-4, IL-5 has not been studied yet. Thus, we aimed to study the IL-4 and IL-5 correlation to central obesity in adolescent Egyptian girls among proinflammatory and anti-inflammatory cytokines. The study was carried out on 86 obese adolescent girls (BMI>95 percentile) divided into two groups according to central obesity. The group I with waist to hip ratio 0.8 (central obesity). There was a significant increase in TNF-alpha (p |
| doi_str_mv | 10.1016/j.cyto.2012.11.010 |
| format | article |
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Several studies have investigated the correlation between central obesity and inflammatory cytokines and the anti-inflammatory cytokine adiponectin. But, the correlation between central obesity and the anti-inflammatory cytokines IL-4, IL-5 has not been studied yet. Thus, we aimed to study the IL-4 and IL-5 correlation to central obesity in adolescent Egyptian girls among proinflammatory and anti-inflammatory cytokines. The study was carried out on 86 obese adolescent girls (BMI>95 percentile) divided into two groups according to central obesity. The group I with waist to hip ratio <0.8 as a control and group II with waist to hip ratio >0.8 (central obesity). There was a significant increase in TNF-alpha (p<0.0001), and IL-1β (p<0.0001), as proinflammatory cytokines in group II, as compared to their corresponding group I. Group II showed a significant increase in the anti-inflammatory cytokines IL-4 and IL-5 than group I at (p<0.0001) and (p<0.0005) respectively. In addition there was a significant decrease in the anti-inflammatory adiponectin and an increase in the inflammatory leptin levels in group II at (p<0.0001) and (p<0.0001) respectively in comparison to group I. A high positive correlation has been observed between waist to hip ratio, leptin, TNF-α, IL-1-β, IL-4 and IL-5 at (r=0.331, p<0.03), (r=0.559, p<0.001), (r=0.435, p<0.004), (r=0.509, p<0.001), (r=0.550, p<0.0015), in group II respectively and a high negative one with adiponectin at (r=−0.410, p<0.0001). We concluded that central obesity lowers adiponectin plasma level through increasing proinflammatory adipokines such as TNF-α, IL-1β, leptin. Further studies are needed to explore the positive correlation we found between central obesity and the anti-inflammatory cytokines IL-4 and IL-5 known to be associated with bronchial asthma.]]></description><identifier>ISSN: 1043-4666</identifier><identifier>EISSN: 1096-0023</identifier><identifier>DOI: 10.1016/j.cyto.2012.11.010</identifier><identifier>PMID: 23306429</identifier><language>eng</language><publisher>England: Elsevier Ltd</publisher><subject>Adipokines ; Adiponectin ; Adiponectin - blood ; Adolescence ; Adolescent ; Adolescent girls ; adolescents ; Anti-Inflammatory Agents - blood ; Anti-inflammatory cytokines ; Asthma ; Central obesity ; Cytokines - blood ; Female ; girls ; Hip ; Humans ; Inflammation ; Inflammation Mediators - blood ; Interleukin 4 ; Interleukin 5 ; Interleukin-1beta - blood ; Interleukin-4 - blood ; Interleukin-5 - blood ; Leptin ; Leptin - blood ; Obesity ; Obesity, Abdominal - blood ; Plasma levels ; Proinflammatory ; Students ; Tumor necrosis factor- alpha ; Waist-Hip Ratio ; waist-to-hip ratio</subject><ispartof>Cytokine (Philadelphia, Pa.), 2013-02, Vol.61 (2), p.682-687</ispartof><rights>2012 Elsevier Ltd</rights><rights>Copyright © 2012 Elsevier Ltd. All rights reserved.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c413t-250c09afd26e39dc31ffb012af08e2147080ac5abe6868e1e89ad569818c3ba33</citedby><cites>FETCH-LOGICAL-c413t-250c09afd26e39dc31ffb012af08e2147080ac5abe6868e1e89ad569818c3ba33</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23306429$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>El-Wakkad, Amany</creatorcontrib><creatorcontrib>Hassan, Nayera El-Morsi</creatorcontrib><creatorcontrib>Sibaii, Hiba</creatorcontrib><creatorcontrib>El-Zayat, Salwa Refat</creatorcontrib><title>Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity</title><title>Cytokine (Philadelphia, Pa.)</title><addtitle>Cytokine</addtitle><description><![CDATA[► Central obesity promotes the secretion of pro-inflammatory TNF-α, IL-1β, leptin. ► Anti-inflammatory IL-4, IL-5 cytokines increase and adiponectin decreases. ► This pointed to the importance of leptin/Adiponectin balance. ► The positive correlation between IL-4, IL-5. ► Points to a possible correlation between central obesity and allergic conditions.
Several studies have investigated the correlation between central obesity and inflammatory cytokines and the anti-inflammatory cytokine adiponectin. But, the correlation between central obesity and the anti-inflammatory cytokines IL-4, IL-5 has not been studied yet. Thus, we aimed to study the IL-4 and IL-5 correlation to central obesity in adolescent Egyptian girls among proinflammatory and anti-inflammatory cytokines. The study was carried out on 86 obese adolescent girls (BMI>95 percentile) divided into two groups according to central obesity. The group I with waist to hip ratio <0.8 as a control and group II with waist to hip ratio >0.8 (central obesity). There was a significant increase in TNF-alpha (p<0.0001), and IL-1β (p<0.0001), as proinflammatory cytokines in group II, as compared to their corresponding group I. Group II showed a significant increase in the anti-inflammatory cytokines IL-4 and IL-5 than group I at (p<0.0001) and (p<0.0005) respectively. In addition there was a significant decrease in the anti-inflammatory adiponectin and an increase in the inflammatory leptin levels in group II at (p<0.0001) and (p<0.0001) respectively in comparison to group I. A high positive correlation has been observed between waist to hip ratio, leptin, TNF-α, IL-1-β, IL-4 and IL-5 at (r=0.331, p<0.03), (r=0.559, p<0.001), (r=0.435, p<0.004), (r=0.509, p<0.001), (r=0.550, p<0.0015), in group II respectively and a high negative one with adiponectin at (r=−0.410, p<0.0001). We concluded that central obesity lowers adiponectin plasma level through increasing proinflammatory adipokines such as TNF-α, IL-1β, leptin. Further studies are needed to explore the positive correlation we found between central obesity and the anti-inflammatory cytokines IL-4 and IL-5 known to be associated with bronchial asthma.]]></description><subject>Adipokines</subject><subject>Adiponectin</subject><subject>Adiponectin - blood</subject><subject>Adolescence</subject><subject>Adolescent</subject><subject>Adolescent girls</subject><subject>adolescents</subject><subject>Anti-Inflammatory Agents - blood</subject><subject>Anti-inflammatory cytokines</subject><subject>Asthma</subject><subject>Central obesity</subject><subject>Cytokines - blood</subject><subject>Female</subject><subject>girls</subject><subject>Hip</subject><subject>Humans</subject><subject>Inflammation</subject><subject>Inflammation Mediators - blood</subject><subject>Interleukin 4</subject><subject>Interleukin 5</subject><subject>Interleukin-1beta - blood</subject><subject>Interleukin-4 - blood</subject><subject>Interleukin-5 - blood</subject><subject>Leptin</subject><subject>Leptin - blood</subject><subject>Obesity</subject><subject>Obesity, Abdominal - blood</subject><subject>Plasma levels</subject><subject>Proinflammatory</subject><subject>Students</subject><subject>Tumor necrosis factor- alpha</subject><subject>Waist-Hip Ratio</subject><subject>waist-to-hip ratio</subject><issn>1043-4666</issn><issn>1096-0023</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNqFkU-P1SAUxYnROOPoF3ChXbqw9V5oeTRxM5n4L5lEE52lIRRulWdbnsDTvG8vTUfjSldc4HcPl3MYe4zQIKB8sW_sKYeGA_IGsQGEO-wcoZc1ABd317oVdSulPGMPUtoDQC92u_vsjAsBsuX9Ofv8IQa_jJOZZ5NDPD2vzJJ9_fdRtb7yzS-Uyp2rjPOHsGx7v1QpHx0tOVU_ff5a2VJGM1VhoOTz6SG7N5op0aPb9YLdvH716eptff3-zbury-vatihyzTuw0JvRcUmid1bgOA7lV2YERRzbHSgwtjMDSSUVIaneuE72CpUVgxHigj3bdA8xfD9Synr2ydI0mYXCMWkU2EnetkL-H-Wq5apTEgrKN9TGkFKkUR-in008aQS9JqD3evVGrwloRF0SKE1PbvWPw0zuT8tvywvwdANGE7T5En3SNx-LQlfiUR3v1xFfbgQVy354ijpZT4sl5yPZrF3w_5rgF5EEocY</recordid><startdate>20130201</startdate><enddate>20130201</enddate><creator>El-Wakkad, Amany</creator><creator>Hassan, Nayera El-Morsi</creator><creator>Sibaii, Hiba</creator><creator>El-Zayat, Salwa Refat</creator><general>Elsevier Ltd</general><scope>FBQ</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope><scope>7T5</scope><scope>H94</scope></search><sort><creationdate>20130201</creationdate><title>Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity</title><author>El-Wakkad, Amany ; Hassan, Nayera El-Morsi ; Sibaii, Hiba ; El-Zayat, Salwa Refat</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c413t-250c09afd26e39dc31ffb012af08e2147080ac5abe6868e1e89ad569818c3ba33</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Adipokines</topic><topic>Adiponectin</topic><topic>Adiponectin - blood</topic><topic>Adolescence</topic><topic>Adolescent</topic><topic>Adolescent girls</topic><topic>adolescents</topic><topic>Anti-Inflammatory Agents - blood</topic><topic>Anti-inflammatory cytokines</topic><topic>Asthma</topic><topic>Central obesity</topic><topic>Cytokines - blood</topic><topic>Female</topic><topic>girls</topic><topic>Hip</topic><topic>Humans</topic><topic>Inflammation</topic><topic>Inflammation Mediators - blood</topic><topic>Interleukin 4</topic><topic>Interleukin 5</topic><topic>Interleukin-1beta - blood</topic><topic>Interleukin-4 - blood</topic><topic>Interleukin-5 - blood</topic><topic>Leptin</topic><topic>Leptin - blood</topic><topic>Obesity</topic><topic>Obesity, Abdominal - blood</topic><topic>Plasma levels</topic><topic>Proinflammatory</topic><topic>Students</topic><topic>Tumor necrosis factor- alpha</topic><topic>Waist-Hip Ratio</topic><topic>waist-to-hip ratio</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>El-Wakkad, Amany</creatorcontrib><creatorcontrib>Hassan, Nayera El-Morsi</creatorcontrib><creatorcontrib>Sibaii, Hiba</creatorcontrib><creatorcontrib>El-Zayat, Salwa Refat</creatorcontrib><collection>AGRIS</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><jtitle>Cytokine (Philadelphia, Pa.)</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>El-Wakkad, Amany</au><au>Hassan, Nayera El-Morsi</au><au>Sibaii, Hiba</au><au>El-Zayat, Salwa Refat</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity</atitle><jtitle>Cytokine (Philadelphia, Pa.)</jtitle><addtitle>Cytokine</addtitle><date>2013-02-01</date><risdate>2013</risdate><volume>61</volume><issue>2</issue><spage>682</spage><epage>687</epage><pages>682-687</pages><issn>1043-4666</issn><eissn>1096-0023</eissn><abstract><![CDATA[► Central obesity promotes the secretion of pro-inflammatory TNF-α, IL-1β, leptin. ► Anti-inflammatory IL-4, IL-5 cytokines increase and adiponectin decreases. ► This pointed to the importance of leptin/Adiponectin balance. ► The positive correlation between IL-4, IL-5. ► Points to a possible correlation between central obesity and allergic conditions.
Several studies have investigated the correlation between central obesity and inflammatory cytokines and the anti-inflammatory cytokine adiponectin. But, the correlation between central obesity and the anti-inflammatory cytokines IL-4, IL-5 has not been studied yet. Thus, we aimed to study the IL-4 and IL-5 correlation to central obesity in adolescent Egyptian girls among proinflammatory and anti-inflammatory cytokines. The study was carried out on 86 obese adolescent girls (BMI>95 percentile) divided into two groups according to central obesity. The group I with waist to hip ratio <0.8 as a control and group II with waist to hip ratio >0.8 (central obesity). There was a significant increase in TNF-alpha (p<0.0001), and IL-1β (p<0.0001), as proinflammatory cytokines in group II, as compared to their corresponding group I. Group II showed a significant increase in the anti-inflammatory cytokines IL-4 and IL-5 than group I at (p<0.0001) and (p<0.0005) respectively. In addition there was a significant decrease in the anti-inflammatory adiponectin and an increase in the inflammatory leptin levels in group II at (p<0.0001) and (p<0.0001) respectively in comparison to group I. A high positive correlation has been observed between waist to hip ratio, leptin, TNF-α, IL-1-β, IL-4 and IL-5 at (r=0.331, p<0.03), (r=0.559, p<0.001), (r=0.435, p<0.004), (r=0.509, p<0.001), (r=0.550, p<0.0015), in group II respectively and a high negative one with adiponectin at (r=−0.410, p<0.0001). We concluded that central obesity lowers adiponectin plasma level through increasing proinflammatory adipokines such as TNF-α, IL-1β, leptin. Further studies are needed to explore the positive correlation we found between central obesity and the anti-inflammatory cytokines IL-4 and IL-5 known to be associated with bronchial asthma.]]></abstract><cop>England</cop><pub>Elsevier Ltd</pub><pmid>23306429</pmid><doi>10.1016/j.cyto.2012.11.010</doi><tpages>6</tpages></addata></record> |
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| subjects | Adipokines Adiponectin Adiponectin - blood Adolescence Adolescent Adolescent girls adolescents Anti-Inflammatory Agents - blood Anti-inflammatory cytokines Asthma Central obesity Cytokines - blood Female girls Hip Humans Inflammation Inflammation Mediators - blood Interleukin 4 Interleukin 5 Interleukin-1beta - blood Interleukin-4 - blood Interleukin-5 - blood Leptin Leptin - blood Obesity Obesity, Abdominal - blood Plasma levels Proinflammatory Students Tumor necrosis factor- alpha Waist-Hip Ratio waist-to-hip ratio |
| title | Proinflammatory, anti-inflammatory cytokines and adiponkines in students with central obesity |
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