Effect of semisynthetic analog of alpha sub(1)-acid glycoprotein on immunomodulatory and antiinflammatory activity of natural glycoproteinglycoprotein on immunomodulatory and antiinflammatory activity of natural glycoprotein

Pseudo- alpha sub(1)-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of alpha sub(1)-acid glycoprotein carbohydrate chains to other polymeric carrier. Similarly to native glycoprotein, the se...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2000-05, Vol.129 (5), p.480-483
Main Authors: Pukhal'skii, AL, Shmarina, G V, Kalashnikova, E A, Shiyan, S D, Kokarovtseva, S N, Pukhal'skaya, DA, Bovin, N V
Format: Article
Language:English
Subjects:
Alternative pathway
Antioxidants
Carbohydrates
Complement activation
Cytokines
Glycoproteins
Immunomodulation
Leukocytes (mononuclear)
Lymphocytes
Peripheral blood
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Summary:Pseudo- alpha sub(1)-acid glycoprotein with carbohydrate chain ratio typical of native form was synthesized by a previously developed original technique of quantitative transfer of alpha sub(1)-acid glycoprotein carbohydrate chains to other polymeric carrier. Similarly to native glycoprotein, the semisynthetic analog inhibited lymphocyte proliferation and stimulated the production of antiinflammatory cytokines by peripheral blood mononuclear leukocytes. However, it possessed no antioxidant activity and did not inhibit complement activation by the alternative pathway. The role of carbohydrate and protein components of alpha sub(1)-acid glycoprotein molecule in the realization of its biological effects is discussed.
ISSN:0007-4888
1573-8221
DOI:10.1007/BF02439809