Immunomodulatory and Anti-inflammatory Effect of p-Coumaric Acid, a Common Dietary Polyphenol on Experimental Inflammation in Rats

ABSTRACT In this study, p -coumaric acid was evaluated for its immunomodulatory and anti-inflammatory properties in vivo . The immunomodulatory effect of p -coumaric acid (100 mg/kg body weight) was assessed by evaluating its effect on cell-mediated immune responses (delayed type hypersensitivity re...

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Bibliographic Details
Published in:Inflammation 2013-02, Vol.36 (1), p.169-176
Main Authors: Pragasam, Samuel Joshua, Venkatesan, Vijayalakshmi, Rasool, MahaboobKhan
Format: Article
Language:English
Subjects:
Animals
Anti-Inflammatory Agents, Non-Steroidal - pharmacology
Antigen-Antibody Complex - blood
Antigen-antibody complexes
Antiinflammatory agents
Antioxidants - pharmacology
Antirheumatic Agents - pharmacology
Arthritis, Experimental - drug therapy
Arthritis, Experimental - immunology
Biomedical and Life Sciences
Biomedicine
Body weight
Confocal microscopy
Coumaric Acids - pharmacology
Female
Hypersensitivity (delayed)
Hypersensitivity, Delayed - drug therapy
Immune response (cell-mediated)
Immunity, Cellular - drug effects
Immunofluorescence
Immunoglobulins
Immunoglobulins - blood
Immunology
Immunomodulation
Immunosuppressive agents
Indomethacin
Indomethacin - pharmacology
Inflammation
Inflammatory diseases
Internal Medicine
Macrophages
Macrophages - drug effects
p-Coumaric acid
Pathology
Phagocytes
Phagocytosis - drug effects
Pharmacology/Toxicology
Polyphenols
Propionates
Rats
Rats, Wistar
Rheumatoid arthritis
Rheumatology
Synovial Membrane - drug effects
Synovial Membrane - metabolism
Tumor necrosis factor- alpha
Tumor Necrosis Factor-alpha - analysis
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Summary:ABSTRACT In this study, p -coumaric acid was evaluated for its immunomodulatory and anti-inflammatory properties in vivo . The immunomodulatory effect of p -coumaric acid (100 mg/kg body weight) was assessed by evaluating its effect on cell-mediated immune responses (delayed type hypersensitivity reaction), serum immunoglobulin levels, and macrophage phagocytic index in rats. The anti-inflammatory effects of p -coumaric acid (100 mg/kg body weight) were investigated by examining its effect on expression of tumor necrosis factor (TNF-α) in synovial tissue by immunofluorescence confocal microscopy and circulating immune complexes in serum of adjuvant-induced arthritic rats. The increased cell-mediated immune responses and macrophage phagocytic index observed in control rats were significantly reduced ( p  
ISSN:0360-3997
1573-2576
DOI:10.1007/s10753-012-9532-8