Pentadecapeptide BPC 157 and the esophagocutaneous fistula healing therapy

Esophagocutaneous fistulas are a failure of the NO-system, due to NO-synthase blockage by the NOS-blocker L-NAME consequently counteracted by l-arginine and gastric pentadecapeptide BPC 157 (l-arginine

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Bibliographic Details
Published in:European journal of pharmacology 2013-02, Vol.701 (1-3), p.203-212
Main Authors: Cesarec, Vedran, Becejac, Tomislav, Misic, Marija, Djakovic, Zeljko, Olujic, Danijela, Drmic, Domagoj, Brcic, Luka, Rokotov, Dinko Stancic, Seiwerth, Sven, Sikiric, Predrag
Format: Article
Language:English
Subjects:
Animals
Arginine - pharmacology
BPC 157
Cutaneous Fistula - drug therapy
Cutaneous Fistula - physiopathology
Drug Interactions
endothelial nitric oxide synthase
eNOS
esophageal diseases
Esophageal Diseases - drug therapy
Esophageal Diseases - physiopathology
esophageal sphincter
Esophagus
Fistula
gastrointestinal system
gene expression
inducible nitric oxide synthase
inflammatory bowel disease
Male
messenger RNA
mortality
NG-Nitroarginine Methyl Ester - pharmacology
nitric oxide
NO-system
Peptide Fragments - pharmacology
Peptide Fragments - therapeutic use
pharmacology
Proteins - pharmacology
Proteins - therapeutic use
Rats
Rats, Wistar
reverse transcriptase polymerase chain reaction
sphincters
therapeutics
Wound Healing - drug effects
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Description
Summary:Esophagocutaneous fistulas are a failure of the NO-system, due to NO-synthase blockage by the NOS-blocker L-NAME consequently counteracted by l-arginine and gastric pentadecapeptide BPC 157 (l-arginine
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2012.11.055