Effects of widely used drugs on micronutrients: A story rarely told

Abstract Vitamins and trace elements are essential to the body, however, deficiencies are frequently observed in the general population. Diet is mostly responsible for these deficiencies but drugs also may play a significant role by influencing their metabolism. These effects are rarely assessed in...

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Published in:Nutrition (Burbank, Los Angeles County, Calif.) Los Angeles County, Calif.), 2013-04, Vol.29 (4), p.605-610
Main Authors: Samaras, Dimitrios, M.D, Samaras, Nikolaos, M.D, Lang, Pierre-Olivier, M.D., M.P.H., Ph.D, Genton, Laurence, M.D, Frangos, Emilia, M.D, Pichard, Claude, M.D., Ph.D
Format: Article
Language:English
Subjects:
Acids
Adverse effect
Animals
Biological and medical sciences
Clinical medicine
Deficiency Diseases - chemically induced
Deficiency Diseases - diet therapy
Deficiency Diseases - epidemiology
Deficiency Diseases - prevention & control
Diabetes
Dietary Supplements
Drug dosages
Drug interactions
Drug therapy
Feeding. Feeding behavior
Food-Drug Interactions
Fundamental and applied biological sciences. Psychology
Gastroenterology and Hepatology
Humans
Micronutrient
Micronutrients
Micronutrients - administration & dosage
Micronutrients - deficiency
Micronutrients - metabolism
Micronutrients - therapeutic use
Nutrient availability
Prescription drugs
Prescription Drugs - adverse effects
Risk
Studies
Trace element
Trace elements
Vegetarianism
Vertebrates: anatomy and physiology, studies on body, several organs or systems
Vitamin
Vitamin C
Vitamins
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Summary:Abstract Vitamins and trace elements are essential to the body, however, deficiencies are frequently observed in the general population. Diet is mostly responsible for these deficiencies but drugs also may play a significant role by influencing their metabolism. These effects are rarely assessed in clinical practice, in part because of limited data available in the literature. Drug-induced micronutrient depletions, however, may be the origin of otherwise unexplained symptoms that might sometimes influence medication compliance. We present various examples of widely prescribed drugs that can precipitate micronutrient deficiencies. This review aims at sensitizing physicians on drug–micronutrient interactions. High-risk population groups also are presented and supplementation protocols are suggested.
ISSN:0899-9007
1873-1244
DOI:10.1016/j.nut.2012.11.011