The Central American Epidemic of CKD

Recent reports have described an apparent epidemic of CKD along the Pacific coast of Central America, such that CKD is a leading cause of death among working-age men in lower-altitude agricultural communities in this region. Given the limited availability of kidney replacement therapies in this regi...

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Bibliographic Details
Published in:Clinical journal of the American Society of Nephrology 2013-03, Vol.8 (3), p.504-511
Main Authors: Weiner, Daniel E, McClean, Michael D, Kaufman, James S, Brooks, Daniel R
Format: Article
Language:English
Subjects:
Adult
Age Factors
Agricultural Workers' Diseases - epidemiology
Agricultural Workers' Diseases - mortality
Agriculture - statistics & numerical data
Central America - epidemiology
Developing Countries
Epidemics
Humans
Male
Middle Aged
Prognosis
Renal Insufficiency, Chronic - epidemiology
Renal Insufficiency, Chronic - mortality
Risk Assessment
Risk Factors
Sex Factors
Young Adult
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Summary:Recent reports have described an apparent epidemic of CKD along the Pacific coast of Central America, such that CKD is a leading cause of death among working-age men in lower-altitude agricultural communities in this region. Given the limited availability of kidney replacement therapies in this region, CKD often is a terminal diagnosis, lending greater urgency to the identification of a modifiable cause. This article discusses the epidemiology of CKD in this region, reviews the clinical features of this CKD outbreak, discusses potential causes and the evidence supporting these hypotheses, and highlights the wider implications of this epidemic of CKD.
ISSN:1555-9041
1555-905X
DOI:10.2215/CJN.05050512