Rate-Dependent Mechanical Properties of Granulated Pharmaceutical Powder Formulations

Pharmaceutical tablets are formed using formulations consisting of ingredients such as filler, binder, disintegrant, and active pharmaceutical ingredients. These ingredients are granulated followed by compaction. In the present study, the granules were formed using 5 and 10% binders. These granulate...

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Bibliographic Details
Published in:Particulate science and technology 2012-03, Vol.30 (2), p.119-135
Main Authors: Pandeya, Anuranjan, Puri, Virendra M.
Format: Article
Language:English
Subjects:
Binders
Bulk modulus
cubical triaxial tester
Failure
Fluid dynamics
Formulations
Granulation
Ingredients
Load
Loading rate
Mechanical properties
Pharmaceuticals
powder compaction
Shear stress
wet granulation
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Summary:Pharmaceutical tablets are formed using formulations consisting of ingredients such as filler, binder, disintegrant, and active pharmaceutical ingredients. These ingredients are granulated followed by compaction. In the present study, the granules were formed using 5 and 10% binders. These granulated formulations were tested to determine mechanical properties using a medium pressure (
ISSN:0272-6351
1548-0046
DOI:10.1080/02726351.2010.550988