Liver resection and transplantation offer similar 5-year survival for Child-Pugh-Turcotte A HCC-patients with a single nodule up to 5 cm: A multicenter, exploratory analysis

Abstract Background and aim The current guideline of the American Association for the Study of Liver Diseases recommends liver resection for Child-Pugh-Turcotte A patients with a single hepatocellular carcinoma, total serum bilirubin ≤1 mg/dL and absence of significant portal hypertension. This subs...

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Bibliographic Details
Published in:European journal of surgical oncology 2013-04, Vol.39 (4), p.386-395
Main Authors: Silva, M.F, Sapisochin, G, Strasser, S.I, Hewa-Geeganage, S, Chen, J, Wigg, A.J, Jones, R, Saraiva, R, Kikuchi, L, Carrilho, F, Fontes, P.R.O, Charco, R
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Australia
Brazil
Carcinoma, Hepatocellular - pathology
Carcinoma, Hepatocellular - surgery
Disease-Free Survival
Female
Hematology, Oncology and Palliative Medicine
Hepatectomy
Hepatocellular carcinoma
Humans
Liver Cirrhosis - pathology
Liver Cirrhosis - surgery
Liver Neoplasms - pathology
Liver Neoplasms - surgery
Liver resection
Liver Transplantation
Male
Middle Aged
Multivariate Analysis
Retrospective Studies
Spain
Surgery
Survival Analysis
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Summary:Abstract Background and aim The current guideline of the American Association for the Study of Liver Diseases recommends liver resection for Child-Pugh-Turcotte A patients with a single hepatocellular carcinoma, total serum bilirubin ≤1 mg/dL and absence of significant portal hypertension. This subset of patients would have a long-term survival comparable to transplantation. The main aim of this study is to evaluate the survival rates in patients with a single nodule ≤5 cm following resection. Methods Medical records of 105 Child-Pugh-Turcotte A patients who underwent liver resection between 1997 and 2009 were analyzed in 3 countries. Results One, 3-, and 5-year survival rate was 97%, 83%, and 66%, respectively, and no variable that can be assessed prior to liver resection predicted survival probabilities. Conclusions Liver resection offers 5-year survival similar to transplantation for Child-Pugh-Turcotte A patients with hepatocellular carcinoma and a single nodule up to 5 cm, independently of any patient baseline characteristics.
ISSN:0748-7983
1532-2157
DOI:10.1016/j.ejso.2012.12.011