Clinical Characteristics, Mortality, Cardiac Hospitalization, and Ventricular Arrhythmias in Patients Undergoing CRT-D Implantation: Results of the ACTION-HF Study

CRT Patient Characteristics and Outcomes. Introduction: The characteristics and outcomes of patients who undergo cardiac resynchronization therapy (CRT) device implantation in current clinical practice may differ from those of reference trial populations. Study objectives were to assess 2‐year outco...

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Published in:Journal of cardiovascular electrophysiology 2013-02, Vol.24 (2), p.173-181
Main Authors: BOTTO, GIOVANNI LUCA, DICANDIA, COSIMO DAMIANO, MANTICA, MASSIMO, ROSA, CONCETTO LA, D'ONOFRIO, ANTONIO, BONGIORNI, MARIA GRAZIA, MOLON, GIULIO, VERLATO, ROBERTO, VILLANI, GIOVANNI QUINTO, SCACCIA, ALBERTO, RACITI, GIOVANNI, OCCHETTA, ERALDO
Format: Article
Language:English
Subjects:
all-cause mortality. atrial fibrillation
Cardiac arrhythmia
cardiac resynchronization therapy
Cardiac Resynchronization Therapy - mortality
Cardiac Resynchronization Therapy - utilization
Cardiac Resynchronization Therapy Devices - utilization
Clinical medicine
COMPANION
Drug therapy
Female
heart failure
Hospitalization - statistics & numerical data
Humans
Incidence
Italy - epidemiology
Male
Mortality
Risk Factors
Survival Analysis
Survival Rate
Tachycardia, Ventricular - mortality
Tachycardia, Ventricular - prevention & control
Treatment Outcome
Ventricular Fibrillation - mortality
Ventricular Fibrillation - prevention & control
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Summary:CRT Patient Characteristics and Outcomes. Introduction: The characteristics and outcomes of patients who undergo cardiac resynchronization therapy (CRT) device implantation in current clinical practice may differ from those of reference trial populations. Study objectives were to assess 2‐year outcomes in a population implanted with a CRT plus defibrillator device in accordance with the standard of care and to evaluate any independent association between clinical variables and outcome. Methods and Results: A total of 406 patients enrolled at 35 centers in Italy were followed up prospectively for 2 years. All patient management decisions were left to the treating physician's discretion, in accordance with clinical practice. ACTION‐HF patients had a better baseline clinical status than patients enrolled in the COMPANION study: shorter HF history (1 vs 3.5 years, P 
ISSN:1045-3873
1540-8167
DOI:10.1111/jce.12023