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Clinical Characteristics, Mortality, Cardiac Hospitalization, and Ventricular Arrhythmias in Patients Undergoing CRT-D Implantation: Results of the ACTION-HF Study
CRT Patient Characteristics and Outcomes. Introduction: The characteristics and outcomes of patients who undergo cardiac resynchronization therapy (CRT) device implantation in current clinical practice may differ from those of reference trial populations. Study objectives were to assess 2‐year outco...
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| Published in: | Journal of cardiovascular electrophysiology 2013-02, Vol.24 (2), p.173-181 |
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| container_end_page | 181 |
| container_issue | 2 |
| container_start_page | 173 |
| container_title | Journal of cardiovascular electrophysiology |
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| creator | BOTTO, GIOVANNI LUCA DICANDIA, COSIMO DAMIANO MANTICA, MASSIMO ROSA, CONCETTO LA D'ONOFRIO, ANTONIO BONGIORNI, MARIA GRAZIA MOLON, GIULIO VERLATO, ROBERTO VILLANI, GIOVANNI QUINTO SCACCIA, ALBERTO RACITI, GIOVANNI OCCHETTA, ERALDO |
| description | CRT Patient Characteristics and Outcomes. Introduction: The characteristics and outcomes of patients who undergo cardiac resynchronization therapy (CRT) device implantation in current clinical practice may differ from those of reference trial populations. Study objectives were to assess 2‐year outcomes in a population implanted with a CRT plus defibrillator device in accordance with the standard of care and to evaluate any independent association between clinical variables and outcome.
Methods and Results:
A total of 406 patients enrolled at 35 centers in Italy were followed up prospectively for 2 years. All patient management decisions were left to the treating physician's discretion, in accordance with clinical practice. ACTION‐HF patients had a better baseline clinical status than patients enrolled in the COMPANION study: shorter HF history (1 vs 3.5 years, P |
| doi_str_mv | 10.1111/jce.12023 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1316376951</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>2879959971</sourcerecordid><originalsourceid>FETCH-LOGICAL-c3913-e22333cd77580c4c132ff321a2cf96bedd66dbb86ffbe447e44bf2d7e67a47243</originalsourceid><addsrcrecordid>eNp1kd9u0zAUhyMEYmNwwQsgS9yA1Gy2T2Kn3HVhW4vGhkoHl5ZjO6u7_Cm2Iwivw4virdsukLBk-ej4O5-O9EuS1wQfkniONsocEoopPEn2SZ7htCCMP401zvIUCg57yQvvNxgTYDh_nuxRIIB5QfaTP2VjO6tkg8q1dFIF46wPVvkJ-ty7IBsbxgkqpdNWKjTv_dbeNn_LYPtugmSn0TfTBWfV0EiHZs6tx7BurfTIduhLxOKvR1edNu66t901Kper9CNatNtGduFO8wEtjR-aiPU1CmuDZuVqcXmRzk_R1zDo8WXyrJaNN6_u34Pk6vRkVc7T88uzRTk7TxVMCaSGUgBQmvO8wCpTBGhdAyWSqnrKKqM1Y7qqClbXlckyHm9VU80N4zLjNIOD5N3Ou3X9j8H4IFrrlWnioqYfvCBAGHA2zUlE3_6DbvrBdXE7QWgBlGbTnEfq_Y5SrvfemVpsnW2lGwXB4jY5EZMTd8lF9s29cahaox_Jh6gicLQDftrGjP83iU_lyYMy3U3ERM2vxwnpbgTjwHPx_eJMHPNimR-zXMzhL5OhsgI</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1283224957</pqid></control><display><type>article</type><title>Clinical Characteristics, Mortality, Cardiac Hospitalization, and Ventricular Arrhythmias in Patients Undergoing CRT-D Implantation: Results of the ACTION-HF Study</title><source>Wiley</source><creator>BOTTO, GIOVANNI LUCA ; DICANDIA, COSIMO DAMIANO ; MANTICA, MASSIMO ; ROSA, CONCETTO LA ; D'ONOFRIO, ANTONIO ; BONGIORNI, MARIA GRAZIA ; MOLON, GIULIO ; VERLATO, ROBERTO ; VILLANI, GIOVANNI QUINTO ; SCACCIA, ALBERTO ; RACITI, GIOVANNI ; OCCHETTA, ERALDO</creator><creatorcontrib>BOTTO, GIOVANNI LUCA ; DICANDIA, COSIMO DAMIANO ; MANTICA, MASSIMO ; ROSA, CONCETTO LA ; D'ONOFRIO, ANTONIO ; BONGIORNI, MARIA GRAZIA ; MOLON, GIULIO ; VERLATO, ROBERTO ; VILLANI, GIOVANNI QUINTO ; SCACCIA, ALBERTO ; RACITI, GIOVANNI ; OCCHETTA, ERALDO</creatorcontrib><description><![CDATA[CRT Patient Characteristics and Outcomes. Introduction: The characteristics and outcomes of patients who undergo cardiac resynchronization therapy (CRT) device implantation in current clinical practice may differ from those of reference trial populations. Study objectives were to assess 2‐year outcomes in a population implanted with a CRT plus defibrillator device in accordance with the standard of care and to evaluate any independent association between clinical variables and outcome.
Methods and Results:
A total of 406 patients enrolled at 35 centers in Italy were followed up prospectively for 2 years. All patient management decisions were left to the treating physician's discretion, in accordance with clinical practice. ACTION‐HF patients had a better baseline clinical status than patients enrolled in the COMPANION study: shorter HF history (1 vs 3.5 years, P < 0.01), less advanced NYHA functional class (III–IV: 73% vs 100%, P < 0.01), higher LVEF (26% vs 21%, P < 0.01), higher SBP (122 vs 112 mmHg, P < 0.01), and less diabetes (27% vs 41%, P < 0.01). This status was reflected in lower mortality (11.5% vs 26%) and a lower incidence of appropriate ICD shocks (12.1% vs 19.3%). AF history was an independent predictor of the combination of all‐cause mortality and cardiac‐cause hospitalization (HR: 3.31; P < 0.001). Recurrent or new atrial arrhythmias were independently associated with the development of ventricular arrhythmias (HR: 3.4; P < 0.001).
Conclusions
: This population appears clinically less compromised and had a lower incidence of adverse clinical outcomes than those of reference trials. However, we recorded a substantial burden of atrial arrhythmias, which was independently associated with a higher incidence of ventricular arrhythmias. (J Cardiovasc Electrophysiol, Vol. 24, pp. 173‐181, February 2013)]]></description><identifier>ISSN: 1045-3873</identifier><identifier>EISSN: 1540-8167</identifier><identifier>DOI: 10.1111/jce.12023</identifier><identifier>PMID: 23130781</identifier><language>eng</language><publisher>Malden, USA: Blackwell Publishing Inc</publisher><subject>all-cause mortality. atrial fibrillation ; Cardiac arrhythmia ; cardiac resynchronization therapy ; Cardiac Resynchronization Therapy - mortality ; Cardiac Resynchronization Therapy - utilization ; Cardiac Resynchronization Therapy Devices - utilization ; Clinical medicine ; COMPANION ; Drug therapy ; Female ; heart failure ; Hospitalization - statistics & numerical data ; Humans ; Incidence ; Italy - epidemiology ; Male ; Mortality ; Risk Factors ; Survival Analysis ; Survival Rate ; Tachycardia, Ventricular - mortality ; Tachycardia, Ventricular - prevention & control ; Treatment Outcome ; Ventricular Fibrillation - mortality ; Ventricular Fibrillation - prevention & control</subject><ispartof>Journal of cardiovascular electrophysiology, 2013-02, Vol.24 (2), p.173-181</ispartof><rights>2012 Wiley Periodicals, Inc.</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c3913-e22333cd77580c4c132ff321a2cf96bedd66dbb86ffbe447e44bf2d7e67a47243</citedby><cites>FETCH-LOGICAL-c3913-e22333cd77580c4c132ff321a2cf96bedd66dbb86ffbe447e44bf2d7e67a47243</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,776,780,27900,27901</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/23130781$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>BOTTO, GIOVANNI LUCA</creatorcontrib><creatorcontrib>DICANDIA, COSIMO DAMIANO</creatorcontrib><creatorcontrib>MANTICA, MASSIMO</creatorcontrib><creatorcontrib>ROSA, CONCETTO LA</creatorcontrib><creatorcontrib>D'ONOFRIO, ANTONIO</creatorcontrib><creatorcontrib>BONGIORNI, MARIA GRAZIA</creatorcontrib><creatorcontrib>MOLON, GIULIO</creatorcontrib><creatorcontrib>VERLATO, ROBERTO</creatorcontrib><creatorcontrib>VILLANI, GIOVANNI QUINTO</creatorcontrib><creatorcontrib>SCACCIA, ALBERTO</creatorcontrib><creatorcontrib>RACITI, GIOVANNI</creatorcontrib><creatorcontrib>OCCHETTA, ERALDO</creatorcontrib><title>Clinical Characteristics, Mortality, Cardiac Hospitalization, and Ventricular Arrhythmias in Patients Undergoing CRT-D Implantation: Results of the ACTION-HF Study</title><title>Journal of cardiovascular electrophysiology</title><addtitle>J Cardiovasc Electrophysiol</addtitle><description><![CDATA[CRT Patient Characteristics and Outcomes. Introduction: The characteristics and outcomes of patients who undergo cardiac resynchronization therapy (CRT) device implantation in current clinical practice may differ from those of reference trial populations. Study objectives were to assess 2‐year outcomes in a population implanted with a CRT plus defibrillator device in accordance with the standard of care and to evaluate any independent association between clinical variables and outcome.
Methods and Results:
A total of 406 patients enrolled at 35 centers in Italy were followed up prospectively for 2 years. All patient management decisions were left to the treating physician's discretion, in accordance with clinical practice. ACTION‐HF patients had a better baseline clinical status than patients enrolled in the COMPANION study: shorter HF history (1 vs 3.5 years, P < 0.01), less advanced NYHA functional class (III–IV: 73% vs 100%, P < 0.01), higher LVEF (26% vs 21%, P < 0.01), higher SBP (122 vs 112 mmHg, P < 0.01), and less diabetes (27% vs 41%, P < 0.01). This status was reflected in lower mortality (11.5% vs 26%) and a lower incidence of appropriate ICD shocks (12.1% vs 19.3%). AF history was an independent predictor of the combination of all‐cause mortality and cardiac‐cause hospitalization (HR: 3.31; P < 0.001). Recurrent or new atrial arrhythmias were independently associated with the development of ventricular arrhythmias (HR: 3.4; P < 0.001).
Conclusions
: This population appears clinically less compromised and had a lower incidence of adverse clinical outcomes than those of reference trials. However, we recorded a substantial burden of atrial arrhythmias, which was independently associated with a higher incidence of ventricular arrhythmias. (J Cardiovasc Electrophysiol, Vol. 24, pp. 173‐181, February 2013)]]></description><subject>all-cause mortality. atrial fibrillation</subject><subject>Cardiac arrhythmia</subject><subject>cardiac resynchronization therapy</subject><subject>Cardiac Resynchronization Therapy - mortality</subject><subject>Cardiac Resynchronization Therapy - utilization</subject><subject>Cardiac Resynchronization Therapy Devices - utilization</subject><subject>Clinical medicine</subject><subject>COMPANION</subject><subject>Drug therapy</subject><subject>Female</subject><subject>heart failure</subject><subject>Hospitalization - statistics & numerical data</subject><subject>Humans</subject><subject>Incidence</subject><subject>Italy - epidemiology</subject><subject>Male</subject><subject>Mortality</subject><subject>Risk Factors</subject><subject>Survival Analysis</subject><subject>Survival Rate</subject><subject>Tachycardia, Ventricular - mortality</subject><subject>Tachycardia, Ventricular - prevention & control</subject><subject>Treatment Outcome</subject><subject>Ventricular Fibrillation - mortality</subject><subject>Ventricular Fibrillation - prevention & control</subject><issn>1045-3873</issn><issn>1540-8167</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp1kd9u0zAUhyMEYmNwwQsgS9yA1Gy2T2Kn3HVhW4vGhkoHl5ZjO6u7_Cm2Iwivw4virdsukLBk-ej4O5-O9EuS1wQfkniONsocEoopPEn2SZ7htCCMP401zvIUCg57yQvvNxgTYDh_nuxRIIB5QfaTP2VjO6tkg8q1dFIF46wPVvkJ-ty7IBsbxgkqpdNWKjTv_dbeNn_LYPtugmSn0TfTBWfV0EiHZs6tx7BurfTIduhLxOKvR1edNu66t901Kper9CNatNtGduFO8wEtjR-aiPU1CmuDZuVqcXmRzk_R1zDo8WXyrJaNN6_u34Pk6vRkVc7T88uzRTk7TxVMCaSGUgBQmvO8wCpTBGhdAyWSqnrKKqM1Y7qqClbXlckyHm9VU80N4zLjNIOD5N3Ou3X9j8H4IFrrlWnioqYfvCBAGHA2zUlE3_6DbvrBdXE7QWgBlGbTnEfq_Y5SrvfemVpsnW2lGwXB4jY5EZMTd8lF9s29cahaox_Jh6gicLQDftrGjP83iU_lyYMy3U3ERM2vxwnpbgTjwHPx_eJMHPNimR-zXMzhL5OhsgI</recordid><startdate>201302</startdate><enddate>201302</enddate><creator>BOTTO, GIOVANNI LUCA</creator><creator>DICANDIA, COSIMO DAMIANO</creator><creator>MANTICA, MASSIMO</creator><creator>ROSA, CONCETTO LA</creator><creator>D'ONOFRIO, ANTONIO</creator><creator>BONGIORNI, MARIA GRAZIA</creator><creator>MOLON, GIULIO</creator><creator>VERLATO, ROBERTO</creator><creator>VILLANI, GIOVANNI QUINTO</creator><creator>SCACCIA, ALBERTO</creator><creator>RACITI, GIOVANNI</creator><creator>OCCHETTA, ERALDO</creator><general>Blackwell Publishing Inc</general><general>Wiley Subscription Services, Inc</general><scope>BSCLL</scope><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7QP</scope><scope>K9.</scope><scope>7X8</scope></search><sort><creationdate>201302</creationdate><title>Clinical Characteristics, Mortality, Cardiac Hospitalization, and Ventricular Arrhythmias in Patients Undergoing CRT-D Implantation: Results of the ACTION-HF Study</title><author>BOTTO, GIOVANNI LUCA ; DICANDIA, COSIMO DAMIANO ; MANTICA, MASSIMO ; ROSA, CONCETTO LA ; D'ONOFRIO, ANTONIO ; BONGIORNI, MARIA GRAZIA ; MOLON, GIULIO ; VERLATO, ROBERTO ; VILLANI, GIOVANNI QUINTO ; SCACCIA, ALBERTO ; RACITI, GIOVANNI ; OCCHETTA, ERALDO</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c3913-e22333cd77580c4c132ff321a2cf96bedd66dbb86ffbe447e44bf2d7e67a47243</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>all-cause mortality. atrial fibrillation</topic><topic>Cardiac arrhythmia</topic><topic>cardiac resynchronization therapy</topic><topic>Cardiac Resynchronization Therapy - mortality</topic><topic>Cardiac Resynchronization Therapy - utilization</topic><topic>Cardiac Resynchronization Therapy Devices - utilization</topic><topic>Clinical medicine</topic><topic>COMPANION</topic><topic>Drug therapy</topic><topic>Female</topic><topic>heart failure</topic><topic>Hospitalization - statistics & numerical data</topic><topic>Humans</topic><topic>Incidence</topic><topic>Italy - epidemiology</topic><topic>Male</topic><topic>Mortality</topic><topic>Risk Factors</topic><topic>Survival Analysis</topic><topic>Survival Rate</topic><topic>Tachycardia, Ventricular - mortality</topic><topic>Tachycardia, Ventricular - prevention & control</topic><topic>Treatment Outcome</topic><topic>Ventricular Fibrillation - mortality</topic><topic>Ventricular Fibrillation - prevention & control</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>BOTTO, GIOVANNI LUCA</creatorcontrib><creatorcontrib>DICANDIA, COSIMO DAMIANO</creatorcontrib><creatorcontrib>MANTICA, MASSIMO</creatorcontrib><creatorcontrib>ROSA, CONCETTO LA</creatorcontrib><creatorcontrib>D'ONOFRIO, ANTONIO</creatorcontrib><creatorcontrib>BONGIORNI, MARIA GRAZIA</creatorcontrib><creatorcontrib>MOLON, GIULIO</creatorcontrib><creatorcontrib>VERLATO, ROBERTO</creatorcontrib><creatorcontrib>VILLANI, GIOVANNI QUINTO</creatorcontrib><creatorcontrib>SCACCIA, ALBERTO</creatorcontrib><creatorcontrib>RACITI, GIOVANNI</creatorcontrib><creatorcontrib>OCCHETTA, ERALDO</creatorcontrib><collection>Istex</collection><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Calcium & Calcified Tissue Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>MEDLINE - Academic</collection><jtitle>Journal of cardiovascular electrophysiology</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>BOTTO, GIOVANNI LUCA</au><au>DICANDIA, COSIMO DAMIANO</au><au>MANTICA, MASSIMO</au><au>ROSA, CONCETTO LA</au><au>D'ONOFRIO, ANTONIO</au><au>BONGIORNI, MARIA GRAZIA</au><au>MOLON, GIULIO</au><au>VERLATO, ROBERTO</au><au>VILLANI, GIOVANNI QUINTO</au><au>SCACCIA, ALBERTO</au><au>RACITI, GIOVANNI</au><au>OCCHETTA, ERALDO</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Clinical Characteristics, Mortality, Cardiac Hospitalization, and Ventricular Arrhythmias in Patients Undergoing CRT-D Implantation: Results of the ACTION-HF Study</atitle><jtitle>Journal of cardiovascular electrophysiology</jtitle><addtitle>J Cardiovasc Electrophysiol</addtitle><date>2013-02</date><risdate>2013</risdate><volume>24</volume><issue>2</issue><spage>173</spage><epage>181</epage><pages>173-181</pages><issn>1045-3873</issn><eissn>1540-8167</eissn><abstract><![CDATA[CRT Patient Characteristics and Outcomes. Introduction: The characteristics and outcomes of patients who undergo cardiac resynchronization therapy (CRT) device implantation in current clinical practice may differ from those of reference trial populations. Study objectives were to assess 2‐year outcomes in a population implanted with a CRT plus defibrillator device in accordance with the standard of care and to evaluate any independent association between clinical variables and outcome.
Methods and Results:
A total of 406 patients enrolled at 35 centers in Italy were followed up prospectively for 2 years. All patient management decisions were left to the treating physician's discretion, in accordance with clinical practice. ACTION‐HF patients had a better baseline clinical status than patients enrolled in the COMPANION study: shorter HF history (1 vs 3.5 years, P < 0.01), less advanced NYHA functional class (III–IV: 73% vs 100%, P < 0.01), higher LVEF (26% vs 21%, P < 0.01), higher SBP (122 vs 112 mmHg, P < 0.01), and less diabetes (27% vs 41%, P < 0.01). This status was reflected in lower mortality (11.5% vs 26%) and a lower incidence of appropriate ICD shocks (12.1% vs 19.3%). AF history was an independent predictor of the combination of all‐cause mortality and cardiac‐cause hospitalization (HR: 3.31; P < 0.001). Recurrent or new atrial arrhythmias were independently associated with the development of ventricular arrhythmias (HR: 3.4; P < 0.001).
Conclusions
: This population appears clinically less compromised and had a lower incidence of adverse clinical outcomes than those of reference trials. However, we recorded a substantial burden of atrial arrhythmias, which was independently associated with a higher incidence of ventricular arrhythmias. (J Cardiovasc Electrophysiol, Vol. 24, pp. 173‐181, February 2013)]]></abstract><cop>Malden, USA</cop><pub>Blackwell Publishing Inc</pub><pmid>23130781</pmid><doi>10.1111/jce.12023</doi><tpages>9</tpages></addata></record> |
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| subjects | all-cause mortality. atrial fibrillation Cardiac arrhythmia cardiac resynchronization therapy Cardiac Resynchronization Therapy - mortality Cardiac Resynchronization Therapy - utilization Cardiac Resynchronization Therapy Devices - utilization Clinical medicine COMPANION Drug therapy Female heart failure Hospitalization - statistics & numerical data Humans Incidence Italy - epidemiology Male Mortality Risk Factors Survival Analysis Survival Rate Tachycardia, Ventricular - mortality Tachycardia, Ventricular - prevention & control Treatment Outcome Ventricular Fibrillation - mortality Ventricular Fibrillation - prevention & control |
| title | Clinical Characteristics, Mortality, Cardiac Hospitalization, and Ventricular Arrhythmias in Patients Undergoing CRT-D Implantation: Results of the ACTION-HF Study |
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