Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy

Abstract Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients...

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Bibliographic Details
Published in:Acta oncologica 2013-04, Vol.52 (3), p.545-552
Main Authors: Fogliata, Antonella, Scorsetti, Marta, Navarria, Piera, Catalano, Maddalena, Clivio, Alessandro, Cozzi, Luca, Lobefalo, Francesca, Nicolini, Giorgia, Palumbo, Valentina, Pellegrini, Chiara, Reggiori, Giacomo, Roggio, Antonella, Vanetti, Eugenio, Alongi, Filippo, Pentimalli, Sara, Mancosu, Pietro
Format: Article
Language:English
Subjects:
Algorithms
Humans
Leg - pathology
Leg Bones - pathology
Muscle Neoplasms - pathology
Muscle Neoplasms - radiotherapy
Organ Size
Organs at Risk - pathology
Photons - adverse effects
Photons - therapeutic use
Proton Therapy - adverse effects
Proton Therapy - methods
Protons - adverse effects
Protons - therapeutic use
Radiation Injuries - prevention & control
Radiotherapy Dosage
Radiotherapy Planning, Computer-Assisted - methods
Radiotherapy, Intensity-Modulated - adverse effects
Radiotherapy, Intensity-Modulated - methods
Sarcoma - pathology
Sarcoma - radiotherapy
Tumor Burden
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Summary:Abstract Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients presenting with soft-tissue sarcoma of the leg were collected for the study. Dose was prescribed to 66.5 Gy in 25 fractions to the planning target volume (PTV) while significant maximum dose to the bone was constrained to 50 Gy. Plans were optimised according to the RapidArc technique with 6 MV photon beams or for intensity modulated protons. RapidArc photon plans were computed with: 1) AAA; 2) Acuros XB as dose to medium; and 3) Acuros XB as dose to water. Results. All plans acceptably met the criteria of target coverage (V95% >90-95%) and bone sparing (D1cm3
ISSN:0284-186X
1651-226X
DOI:10.3109/0284186X.2012.689853