Loading…
Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy
Abstract Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients...
Saved in:
| Published in: | Acta oncologica 2013-04, Vol.52 (3), p.545-552 |
|---|---|
| Main Authors: | , , , , , , , , , , , , , , , |
| Format: | Article |
| Language: | English |
| Subjects: | |
| Citations: | Items that this one cites Items that cite this one |
| Online Access: | Get full text |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| cited_by | cdi_FETCH-LOGICAL-c408t-3237a17cbe4104496d132cb1bec543df91bd0b5f72d89f8ae22ea071bf703a6f3 |
|---|---|
| cites | cdi_FETCH-LOGICAL-c408t-3237a17cbe4104496d132cb1bec543df91bd0b5f72d89f8ae22ea071bf703a6f3 |
| container_end_page | 552 |
| container_issue | 3 |
| container_start_page | 545 |
| container_title | Acta oncologica |
| container_volume | 52 |
| creator | Fogliata, Antonella Scorsetti, Marta Navarria, Piera Catalano, Maddalena Clivio, Alessandro Cozzi, Luca Lobefalo, Francesca Nicolini, Giorgia Palumbo, Valentina Pellegrini, Chiara Reggiori, Giacomo Roggio, Antonella Vanetti, Eugenio Alongi, Filippo Pentimalli, Sara Mancosu, Pietro |
| description | Abstract
Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients presenting with soft-tissue sarcoma of the leg were collected for the study. Dose was prescribed to 66.5 Gy in 25 fractions to the planning target volume (PTV) while significant maximum dose to the bone was constrained to 50 Gy. Plans were optimised according to the RapidArc technique with 6 MV photon beams or for intensity modulated protons. RapidArc photon plans were computed with: 1) AAA; 2) Acuros XB as dose to medium; and 3) Acuros XB as dose to water. Results. All plans acceptably met the criteria of target coverage (V95% >90-95%) and bone sparing (D1cm3 |
| doi_str_mv | 10.3109/0284186X.2012.689853 |
| format | article |
| fullrecord | <record><control><sourceid>proquest_cross</sourceid><recordid>TN_cdi_proquest_miscellaneous_1316378863</recordid><sourceformat>XML</sourceformat><sourcesystem>PC</sourcesystem><sourcerecordid>1316378863</sourcerecordid><originalsourceid>FETCH-LOGICAL-c408t-3237a17cbe4104496d132cb1bec543df91bd0b5f72d89f8ae22ea071bf703a6f3</originalsourceid><addsrcrecordid>eNp9kE1v1DAQhi0EokvhHyDkI5cs_kgc54JUlU-pFZe26s2a2GPWVRIvtqOqF347Xm3Lsac5zDPzzjyEvOdsKzkbPjGhW67V7VYwLrZKD7qTL8iGq443Qqjbl2RzQJoDc0Le5HzHGBOy716Tk9rvederDfn7JeYwY0nBUhvnPaSQ40JHLPeIC725PLui96HsqAveY8KlUBczUguTXScoocIw_Y6pMnOmsDi6T7HEJVMfE83Rl6aEnFekGVJNAJrAhVh2mGD_8Ja88jBlfPdYT8n1t69X5z-ai1_ff56fXTS2Zbo0st4NvLcjtpy17aAcl8KOfETbtdL5gY-OjZ3vhdOD14BCILCej75nEpSXp-TjcW897s-KuZg5ZIvTBAvGNRsuuZK91kpWtD2iNsWcE3qzT2GG9GA4Mwfz5sm8OZg3R_N17MNjwjrO6P4PPamuwOcjEJZqZoYdwlR2FhKau7impb7_fMI_QYuV2Q</addsrcrecordid><sourcetype>Aggregation Database</sourcetype><iscdi>true</iscdi><recordtype>article</recordtype><pqid>1316378863</pqid></control><display><type>article</type><title>Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy</title><source>Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list)</source><creator>Fogliata, Antonella ; Scorsetti, Marta ; Navarria, Piera ; Catalano, Maddalena ; Clivio, Alessandro ; Cozzi, Luca ; Lobefalo, Francesca ; Nicolini, Giorgia ; Palumbo, Valentina ; Pellegrini, Chiara ; Reggiori, Giacomo ; Roggio, Antonella ; Vanetti, Eugenio ; Alongi, Filippo ; Pentimalli, Sara ; Mancosu, Pietro</creator><creatorcontrib>Fogliata, Antonella ; Scorsetti, Marta ; Navarria, Piera ; Catalano, Maddalena ; Clivio, Alessandro ; Cozzi, Luca ; Lobefalo, Francesca ; Nicolini, Giorgia ; Palumbo, Valentina ; Pellegrini, Chiara ; Reggiori, Giacomo ; Roggio, Antonella ; Vanetti, Eugenio ; Alongi, Filippo ; Pentimalli, Sara ; Mancosu, Pietro</creatorcontrib><description>Abstract
Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients presenting with soft-tissue sarcoma of the leg were collected for the study. Dose was prescribed to 66.5 Gy in 25 fractions to the planning target volume (PTV) while significant maximum dose to the bone was constrained to 50 Gy. Plans were optimised according to the RapidArc technique with 6 MV photon beams or for intensity modulated protons. RapidArc photon plans were computed with: 1) AAA; 2) Acuros XB as dose to medium; and 3) Acuros XB as dose to water. Results. All plans acceptably met the criteria of target coverage (V95% >90-95%) and bone sparing (D1cm3 <50 Gy). Significantly higher PTV dose homogeneity was found for proton plans. Near-to-maximum dose to bone was similar for RapidArc and protons, while volume receiving medium/low dose levels was minimised with protons. Similar results were obtained for the remaining normal tissue. Dose distributions calculated with the dose to water option resulted ∼5% higher than corresponding ones computed as dose to medium. Conclusion. High plan quality was demonstrated for both VMAT and proton techniques when applied to soft-tissue sarcoma.</description><identifier>ISSN: 0284-186X</identifier><identifier>EISSN: 1651-226X</identifier><identifier>DOI: 10.3109/0284186X.2012.689853</identifier><identifier>PMID: 22671576</identifier><language>eng</language><publisher>England: Informa Healthcare</publisher><subject>Algorithms ; Humans ; Leg - pathology ; Leg Bones - pathology ; Muscle Neoplasms - pathology ; Muscle Neoplasms - radiotherapy ; Organ Size ; Organs at Risk - pathology ; Photons - adverse effects ; Photons - therapeutic use ; Proton Therapy - adverse effects ; Proton Therapy - methods ; Protons - adverse effects ; Protons - therapeutic use ; Radiation Injuries - prevention & control ; Radiotherapy Dosage ; Radiotherapy Planning, Computer-Assisted - methods ; Radiotherapy, Intensity-Modulated - adverse effects ; Radiotherapy, Intensity-Modulated - methods ; Sarcoma - pathology ; Sarcoma - radiotherapy ; Tumor Burden</subject><ispartof>Acta oncologica, 2013-04, Vol.52 (3), p.545-552</ispartof><rights>2013 Informa Healthcare 2013</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c408t-3237a17cbe4104496d132cb1bec543df91bd0b5f72d89f8ae22ea071bf703a6f3</citedby><cites>FETCH-LOGICAL-c408t-3237a17cbe4104496d132cb1bec543df91bd0b5f72d89f8ae22ea071bf703a6f3</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/22671576$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Fogliata, Antonella</creatorcontrib><creatorcontrib>Scorsetti, Marta</creatorcontrib><creatorcontrib>Navarria, Piera</creatorcontrib><creatorcontrib>Catalano, Maddalena</creatorcontrib><creatorcontrib>Clivio, Alessandro</creatorcontrib><creatorcontrib>Cozzi, Luca</creatorcontrib><creatorcontrib>Lobefalo, Francesca</creatorcontrib><creatorcontrib>Nicolini, Giorgia</creatorcontrib><creatorcontrib>Palumbo, Valentina</creatorcontrib><creatorcontrib>Pellegrini, Chiara</creatorcontrib><creatorcontrib>Reggiori, Giacomo</creatorcontrib><creatorcontrib>Roggio, Antonella</creatorcontrib><creatorcontrib>Vanetti, Eugenio</creatorcontrib><creatorcontrib>Alongi, Filippo</creatorcontrib><creatorcontrib>Pentimalli, Sara</creatorcontrib><creatorcontrib>Mancosu, Pietro</creatorcontrib><title>Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy</title><title>Acta oncologica</title><addtitle>Acta Oncol</addtitle><description>Abstract
Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients presenting with soft-tissue sarcoma of the leg were collected for the study. Dose was prescribed to 66.5 Gy in 25 fractions to the planning target volume (PTV) while significant maximum dose to the bone was constrained to 50 Gy. Plans were optimised according to the RapidArc technique with 6 MV photon beams or for intensity modulated protons. RapidArc photon plans were computed with: 1) AAA; 2) Acuros XB as dose to medium; and 3) Acuros XB as dose to water. Results. All plans acceptably met the criteria of target coverage (V95% >90-95%) and bone sparing (D1cm3 <50 Gy). Significantly higher PTV dose homogeneity was found for proton plans. Near-to-maximum dose to bone was similar for RapidArc and protons, while volume receiving medium/low dose levels was minimised with protons. Similar results were obtained for the remaining normal tissue. Dose distributions calculated with the dose to water option resulted ∼5% higher than corresponding ones computed as dose to medium. Conclusion. High plan quality was demonstrated for both VMAT and proton techniques when applied to soft-tissue sarcoma.</description><subject>Algorithms</subject><subject>Humans</subject><subject>Leg - pathology</subject><subject>Leg Bones - pathology</subject><subject>Muscle Neoplasms - pathology</subject><subject>Muscle Neoplasms - radiotherapy</subject><subject>Organ Size</subject><subject>Organs at Risk - pathology</subject><subject>Photons - adverse effects</subject><subject>Photons - therapeutic use</subject><subject>Proton Therapy - adverse effects</subject><subject>Proton Therapy - methods</subject><subject>Protons - adverse effects</subject><subject>Protons - therapeutic use</subject><subject>Radiation Injuries - prevention & control</subject><subject>Radiotherapy Dosage</subject><subject>Radiotherapy Planning, Computer-Assisted - methods</subject><subject>Radiotherapy, Intensity-Modulated - adverse effects</subject><subject>Radiotherapy, Intensity-Modulated - methods</subject><subject>Sarcoma - pathology</subject><subject>Sarcoma - radiotherapy</subject><subject>Tumor Burden</subject><issn>0284-186X</issn><issn>1651-226X</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2013</creationdate><recordtype>article</recordtype><recordid>eNp9kE1v1DAQhi0EokvhHyDkI5cs_kgc54JUlU-pFZe26s2a2GPWVRIvtqOqF347Xm3Lsac5zDPzzjyEvOdsKzkbPjGhW67V7VYwLrZKD7qTL8iGq443Qqjbl2RzQJoDc0Le5HzHGBOy716Tk9rvederDfn7JeYwY0nBUhvnPaSQ40JHLPeIC725PLui96HsqAveY8KlUBczUguTXScoocIw_Y6pMnOmsDi6T7HEJVMfE83Rl6aEnFekGVJNAJrAhVh2mGD_8Ja88jBlfPdYT8n1t69X5z-ai1_ff56fXTS2Zbo0st4NvLcjtpy17aAcl8KOfETbtdL5gY-OjZ3vhdOD14BCILCej75nEpSXp-TjcW897s-KuZg5ZIvTBAvGNRsuuZK91kpWtD2iNsWcE3qzT2GG9GA4Mwfz5sm8OZg3R_N17MNjwjrO6P4PPamuwOcjEJZqZoYdwlR2FhKau7impb7_fMI_QYuV2Q</recordid><startdate>201304</startdate><enddate>201304</enddate><creator>Fogliata, Antonella</creator><creator>Scorsetti, Marta</creator><creator>Navarria, Piera</creator><creator>Catalano, Maddalena</creator><creator>Clivio, Alessandro</creator><creator>Cozzi, Luca</creator><creator>Lobefalo, Francesca</creator><creator>Nicolini, Giorgia</creator><creator>Palumbo, Valentina</creator><creator>Pellegrini, Chiara</creator><creator>Reggiori, Giacomo</creator><creator>Roggio, Antonella</creator><creator>Vanetti, Eugenio</creator><creator>Alongi, Filippo</creator><creator>Pentimalli, Sara</creator><creator>Mancosu, Pietro</creator><general>Informa Healthcare</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7X8</scope></search><sort><creationdate>201304</creationdate><title>Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy</title><author>Fogliata, Antonella ; Scorsetti, Marta ; Navarria, Piera ; Catalano, Maddalena ; Clivio, Alessandro ; Cozzi, Luca ; Lobefalo, Francesca ; Nicolini, Giorgia ; Palumbo, Valentina ; Pellegrini, Chiara ; Reggiori, Giacomo ; Roggio, Antonella ; Vanetti, Eugenio ; Alongi, Filippo ; Pentimalli, Sara ; Mancosu, Pietro</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c408t-3237a17cbe4104496d132cb1bec543df91bd0b5f72d89f8ae22ea071bf703a6f3</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2013</creationdate><topic>Algorithms</topic><topic>Humans</topic><topic>Leg - pathology</topic><topic>Leg Bones - pathology</topic><topic>Muscle Neoplasms - pathology</topic><topic>Muscle Neoplasms - radiotherapy</topic><topic>Organ Size</topic><topic>Organs at Risk - pathology</topic><topic>Photons - adverse effects</topic><topic>Photons - therapeutic use</topic><topic>Proton Therapy - adverse effects</topic><topic>Proton Therapy - methods</topic><topic>Protons - adverse effects</topic><topic>Protons - therapeutic use</topic><topic>Radiation Injuries - prevention & control</topic><topic>Radiotherapy Dosage</topic><topic>Radiotherapy Planning, Computer-Assisted - methods</topic><topic>Radiotherapy, Intensity-Modulated - adverse effects</topic><topic>Radiotherapy, Intensity-Modulated - methods</topic><topic>Sarcoma - pathology</topic><topic>Sarcoma - radiotherapy</topic><topic>Tumor Burden</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Fogliata, Antonella</creatorcontrib><creatorcontrib>Scorsetti, Marta</creatorcontrib><creatorcontrib>Navarria, Piera</creatorcontrib><creatorcontrib>Catalano, Maddalena</creatorcontrib><creatorcontrib>Clivio, Alessandro</creatorcontrib><creatorcontrib>Cozzi, Luca</creatorcontrib><creatorcontrib>Lobefalo, Francesca</creatorcontrib><creatorcontrib>Nicolini, Giorgia</creatorcontrib><creatorcontrib>Palumbo, Valentina</creatorcontrib><creatorcontrib>Pellegrini, Chiara</creatorcontrib><creatorcontrib>Reggiori, Giacomo</creatorcontrib><creatorcontrib>Roggio, Antonella</creatorcontrib><creatorcontrib>Vanetti, Eugenio</creatorcontrib><creatorcontrib>Alongi, Filippo</creatorcontrib><creatorcontrib>Pentimalli, Sara</creatorcontrib><creatorcontrib>Mancosu, Pietro</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>MEDLINE - Academic</collection><jtitle>Acta oncologica</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Fogliata, Antonella</au><au>Scorsetti, Marta</au><au>Navarria, Piera</au><au>Catalano, Maddalena</au><au>Clivio, Alessandro</au><au>Cozzi, Luca</au><au>Lobefalo, Francesca</au><au>Nicolini, Giorgia</au><au>Palumbo, Valentina</au><au>Pellegrini, Chiara</au><au>Reggiori, Giacomo</au><au>Roggio, Antonella</au><au>Vanetti, Eugenio</au><au>Alongi, Filippo</au><au>Pentimalli, Sara</au><au>Mancosu, Pietro</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy</atitle><jtitle>Acta oncologica</jtitle><addtitle>Acta Oncol</addtitle><date>2013-04</date><risdate>2013</risdate><volume>52</volume><issue>3</issue><spage>545</spage><epage>552</epage><pages>545-552</pages><issn>0284-186X</issn><eissn>1651-226X</eissn><abstract>Abstract
Background. To appraise the potential of volumetric modulated arc therapy (VMAT, RapidArc) and proton beams to simultaneously achieve target coverage and enhanced sparing of bone tissue in the treatment of soft-tissue sarcoma with adequate target coverage. Material and methods. Ten patients presenting with soft-tissue sarcoma of the leg were collected for the study. Dose was prescribed to 66.5 Gy in 25 fractions to the planning target volume (PTV) while significant maximum dose to the bone was constrained to 50 Gy. Plans were optimised according to the RapidArc technique with 6 MV photon beams or for intensity modulated protons. RapidArc photon plans were computed with: 1) AAA; 2) Acuros XB as dose to medium; and 3) Acuros XB as dose to water. Results. All plans acceptably met the criteria of target coverage (V95% >90-95%) and bone sparing (D1cm3 <50 Gy). Significantly higher PTV dose homogeneity was found for proton plans. Near-to-maximum dose to bone was similar for RapidArc and protons, while volume receiving medium/low dose levels was minimised with protons. Similar results were obtained for the remaining normal tissue. Dose distributions calculated with the dose to water option resulted ∼5% higher than corresponding ones computed as dose to medium. Conclusion. High plan quality was demonstrated for both VMAT and proton techniques when applied to soft-tissue sarcoma.</abstract><cop>England</cop><pub>Informa Healthcare</pub><pmid>22671576</pmid><doi>10.3109/0284186X.2012.689853</doi><tpages>8</tpages><oa>free_for_read</oa></addata></record> |
| fulltext | fulltext |
| identifier | ISSN: 0284-186X |
| ispartof | Acta oncologica, 2013-04, Vol.52 (3), p.545-552 |
| issn | 0284-186X 1651-226X |
| language | eng |
| recordid | cdi_proquest_miscellaneous_1316378863 |
| source | Taylor and Francis:Jisc Collections:Taylor and Francis Read and Publish Agreement 2024-2025:Medical Collection (Reading list) |
| subjects | Algorithms Humans Leg - pathology Leg Bones - pathology Muscle Neoplasms - pathology Muscle Neoplasms - radiotherapy Organ Size Organs at Risk - pathology Photons - adverse effects Photons - therapeutic use Proton Therapy - adverse effects Proton Therapy - methods Protons - adverse effects Protons - therapeutic use Radiation Injuries - prevention & control Radiotherapy Dosage Radiotherapy Planning, Computer-Assisted - methods Radiotherapy, Intensity-Modulated - adverse effects Radiotherapy, Intensity-Modulated - methods Sarcoma - pathology Sarcoma - radiotherapy Tumor Burden |
| title | Dosimetric comparison between VMAT with different dose calculation algorithms and protons for soft-tissue sarcoma radiotherapy |
| url | http://sfxeu10.hosted.exlibrisgroup.com/loughborough?ctx_ver=Z39.88-2004&ctx_enc=info:ofi/enc:UTF-8&ctx_tim=2025-01-07T05%3A41%3A10IST&url_ver=Z39.88-2004&url_ctx_fmt=infofi/fmt:kev:mtx:ctx&rfr_id=info:sid/primo.exlibrisgroup.com:primo3-Article-proquest_cross&rft_val_fmt=info:ofi/fmt:kev:mtx:journal&rft.genre=article&rft.atitle=Dosimetric%20comparison%20between%20VMAT%20with%20different%20dose%20calculation%20algorithms%20and%20protons%20for%20soft-tissue%20sarcoma%20radiotherapy&rft.jtitle=Acta%20oncologica&rft.au=Fogliata,%20Antonella&rft.date=2013-04&rft.volume=52&rft.issue=3&rft.spage=545&rft.epage=552&rft.pages=545-552&rft.issn=0284-186X&rft.eissn=1651-226X&rft_id=info:doi/10.3109/0284186X.2012.689853&rft_dat=%3Cproquest_cross%3E1316378863%3C/proquest_cross%3E%3Cgrp_id%3Ecdi_FETCH-LOGICAL-c408t-3237a17cbe4104496d132cb1bec543df91bd0b5f72d89f8ae22ea071bf703a6f3%3C/grp_id%3E%3Coa%3E%3C/oa%3E%3Curl%3E%3C/url%3E&rft_id=info:oai/&rft_pqid=1316378863&rft_id=info:pmid/22671576&rfr_iscdi=true |