Free and nanoencapsulated curcumin prevents cigarette smoke-induced cognitive impairment and redox imbalance

• Published in: Neurobiology of learning and memory 2013-02, Vol.100, p.98-107
• Main Authors: Jaques, Jeandre Augusto dos Santos, Doleski, Pedro Henrique, Castilhos, Lívia Gelain, da Rosa, Michelle Melgarejo, Souza, Viviane do Carmo Gonçalves, Carvalho, Fabiano Barbosa, Marisco, Patrícia, Thorstenberg, Maria Luiza Prates, Rezer, João Felipe Peres, Ruchel, Jader Betch, Coradini, Karine, Beck, Ruy Carlos Ruver, Rubin, Maribel Antonello, Schetinger, Maria Rosa Chitolina, Leal, Daniela Bitencourt Rosa
• Format: Article
• Language: English
• Subjects: Addictive behaviors; Adult and adolescent clinical studies; Animals; Behavior, Animal - drug effects; Behavior, Animal - physiology; Behavioral psychophysiology; Bioavailability; Biological and medical sciences; Cigarette; Cognition & reasoning; Cognition Disorders - chemically induced; Cognition Disorders - metabolism; Cognition Disorders - prevention & control; Cognitive impairment; Curcumin; Curcumin - pharmacology; Fundamental and applied biological sciences. Psychology; Glutathione Peroxidase - metabolism; Lipid Peroxidation - drug effects; Lipid-core nanocapsules; Male; Medical sciences; Memory; Memory - drug effects; Memory - physiology; Motor Activity - drug effects; Motor Activity - physiology; Neurobiology; Oxidation-Reduction; Oxidative stress; Oxidative Stress - drug effects; Polyphenols; Psychology. Psychoanalysis. Psychiatry; Psychology. Psychophysiology; Psychopathology. Psychiatry; Rats; Rats, Wistar; Smoke - adverse effects; Sodium-Potassium-Exchanging ATPase - metabolism; Superoxide Dismutase - metabolism; Thiobarbituric Acid Reactive Substances - metabolism; Tobacco smoke; Tobacco smoking; Tobacco, tobacco smoking; Toxicology
• ISSN: 1074-7427; 1095-9564; 1095-9564
• DOI: 10.1016/j.nlm.2012.12.007

► Curcumin free and C-LNC prevented tobacco-induced cognitive impairment. ► Curcumin free and C-LNC prevented tobacco-induced decrease in the ATPases activities. ► Curcumin free and C-LNC protected against tobacco-induced redox imbalance. ► Curcumin free and C-LNC might be promising in the treatment of cognitive dysfunctions. ► Our data indicate that C-LNC may be an alternative to curcumin’s poor bioavailability. Cigarette smoke-exposure promotes neurobiological changes associated with neurocognitive abnormalities. Curcumin, a natural polyphenol, have shown to be able to prevent cigarette smoke-induced cognitive impairment. Here, we investigated possible mechanisms involved in curcumin protection against cigarette smoke-induced cognitive impairment and, due to its poor bioavailability, we investigated the potential of using curcumin-loaded lipid-core nanocapsules (C-LNC) suspension. Rats were treated with curcumin and cigarette smoke, once a day, 5days each week, for 30days. Animals were divided into ten groups: I, control (vehicle/corn oil); II, curcumin 12.5mg/kg; III, curcumin 25mg/kg; IV, curcumin 50mg/kg; V, C-LNC 4mg/kg; VI, tobacco exposed; VII, curcumin 12.5mg/kg along with tobacco exposure; VIII, curcumin 25mg/kg along with tobacco exposure; IX, curcumin 50mg/kg along with tobacco exposure; X, C-LNC 4mg/kg along with tobacco exposure. Cigarette smoke-exposure impaired object recognition memory (P