Regeneration of Cirrhotic Liver in Rabbits after Intrahepatic Injection of Cryoprecipitate

The stimulatory effect of cryoprecipitate on liver regeneration was studied in rabbits with cirrhosis of the liver induced by subcutaneous injection of tetrachloromethane. Cryoprecipitate stimulated the hepatocyte regeneration (appearance of binuclear and proliferating cells) in liver tissue in cirr...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013, Vol.154 (3), p.396-398
Main Authors: Chernousov, A. F., Khorobrykh, T. V., Karpova, R. V., Nekrasova, T. P.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Carbon Tetrachloride
Cell Biology
Cell Proliferation
Factor VIII - administration & dosage
Fibrin
Fibrinogen - administration & dosage
Fibronectins
Hepatocytes - drug effects
Hepatocytes - metabolism
Internal Medicine
Laboratory Medicine
Liver
Liver - drug effects
Liver - pathology
Liver cirrhosis
Liver Cirrhosis, Experimental - chemically induced
Liver Cirrhosis, Experimental - drug therapy
Liver Cirrhosis, Experimental - metabolism
Liver Regeneration - drug effects
Pathology
Rabbits
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Summary:The stimulatory effect of cryoprecipitate on liver regeneration was studied in rabbits with cirrhosis of the liver induced by subcutaneous injection of tetrachloromethane. Cryoprecipitate stimulated the hepatocyte regeneration (appearance of binuclear and proliferating cells) in liver tissue in cirrhosis, but the initial structure of the liver was not restored. The newly formed focus of regeneration with proper girder structure of hepatocytes forced back the connective tissue. Highly concentrated solution of fibrinogen, injected by puncture method into cirrhotic hepatic tissue, stimulated its regeneration.
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-1959-x