The ultrastructure of animal atherosclerosis: What has been done, and the electron microscopy advancements that could help scientists answer new biological questions

► A summary of the ultrastructure of atherosclerosis as known in the mid 1990s. ► Contributions of EM in the understanding of animal atherosclerosis since 1995. ► Technical developments that are of interest for future ultrastructural research. Electron microscopy is a powerful technique that has bee...

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Bibliographic Details
Published in:Micron (Oxford, England : 1993) England : 1993), 2013-03, Vol.46, p.1-11
Main Authors: Tranfield, Erin M., Walker, David C.
Format: Article
Language:English
Subjects:
Animal models
Animals
Atherosclerosis
Atherosclerosis - pathology
Disease Models, Animal
Electron microscopy
Electron tomography
High pressure freezing
History, 20th Century
History, 21st Century
Microscopy, Electron - methods
Pathology - history
Pathology - methods
Pathology - trends
physiology
ultrastructure
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Summary:► A summary of the ultrastructure of atherosclerosis as known in the mid 1990s. ► Contributions of EM in the understanding of animal atherosclerosis since 1995. ► Technical developments that are of interest for future ultrastructural research. Electron microscopy is a powerful technique that has been used to answer numerous structure related research questions in all fields, including atherosclerotic research. Recent technology developments are expanding the capabilities of electron microscopy to address the physiology and pathology of arterial function. The purpose of this review is to describe what was known about the ultrastructure of atherosclerosis in the mid 1990s, what has been added to this knowledge basis since then, and to detail some of the recent electron microscopy techniques that could allow us to shed light on hitherto unaddressed aspects of this disease.
ISSN:0968-4328
1878-4291
DOI:10.1016/j.micron.2012.12.001