Soluble ST2 as a Biomarker for Detecting Stable Heart Failure With a Normal Ejection Fraction in Hypertensive Patients

Abstract Background We investigated the measurement of soluble ST2 (sST2) in stable heart failure (HF) with a normal ejection fraction (HFNEF) in hypertensive patients. Methods and Results Echocardiography and serum N-terminal pro–B-type natriuretic peptide (NT-proBNP) and sST2 concentrations were e...

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Bibliographic Details
Published in:Journal of cardiac failure 2013-03, Vol.19 (3), p.163-168
Main Authors: Wang, Yi-Chih, MD, Yu, Chih-Chieh, MD, Chiu, Fu-Chun, MD, Tsai, Chia-Ti, MD, PhD, Lai, Ling-Ping, MD, PhD, Hwang, Juey-Jen, MD, PhD, Lin, Jiunn-Lee, MD, PhD
Format: Article
Language:English
Subjects:
Aged
Biomarkers
Biomarkers - blood
Cardiovascular
diastolic function
echocardiography
Female
Heart Failure - blood
Heart Failure - diagnosis
Heart Failure - epidemiology
heart failure with normal ejection fraction
Humans
Hypertension - blood
Hypertension - diagnosis
Hypertension - epidemiology
Interleukin-1 Receptor-Like 1 Protein
Male
Middle Aged
Receptors, Cell Surface - blood
Stroke Volume - physiology
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Summary:Abstract Background We investigated the measurement of soluble ST2 (sST2) in stable heart failure (HF) with a normal ejection fraction (HFNEF) in hypertensive patients. Methods and Results Echocardiography and serum N-terminal pro–B-type natriuretic peptide (NT-proBNP) and sST2 concentrations were evaluated in 107 hypertensive patients (65 ± 12 years, 57 male) with ejection fraction (EF) >50%. Among them, 68 patients with stable HF in functional class II and III were the HFNEF group. We found that the area under the receiver operating characteristic curve (AUC) for sST2 was 0.80 (95% CI 0.70–0.89; P  13.5 ng/mL was independently associated with HFNEF in hypertensive patients (odds ratio 11.7, 95% CI = 2.9–47.4; P  = .001). Conclusions sST2 measurement provides diagnostic aid of stable HFNEF for hypertensive patients. Addition of NT-proBNP to sST2 could give further information regarding HF functional class and diastolic abnormality.
ISSN:1071-9164
1532-8414
DOI:10.1016/j.cardfail.2013.01.010