Effect of Coenzyme Q10 on the Proteomic Profile of the Cytosolic and Microsomal Fractions from Rat Hepatocytes upon Dietary Consumption of Various Lipid Components during Ontogeny

We studied proteomic features of subcellular fractions from rat hepatocytes and intensity of enzymatic and non-enzymatic free radical oxidation depending on the type of dietary fat during adaptation of animals to modified nutrition. Our results illustrate the formation of specific nutriproteomes in...

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Bibliographic Details
Published in:Bulletin of experimental biology and medicine 2013, Vol.154 (3), p.320-325
Main Authors: Sharanova, N. E., Kulakova, S. N., Baturina, V. A., Toropygin, I. Yu, Khriapova, E. A., Vasilyev, A. V., Gapparov, M. M. G.
Format: Article
Language:English
Subjects:
Animals
Biomedical and Life Sciences
Biomedicine
Cell Biology
Cytosol - drug effects
Diet
Dietary Fats
Free Radicals - chemistry
Hepatocytes - drug effects
Hepatocytes - metabolism
Internal Medicine
Laboratory Medicine
Lipid Metabolism - drug effects
Lipids - chemistry
Liver - drug effects
Liver - enzymology
Male
Pathology
Proteomics
Rats
Subcellular Fractions - drug effects
Ubiquinone - administration & dosage
Ubiquinone - analogs & derivatives
Ubiquinone - metabolism
Ubiquinone - pharmacology
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Summary:We studied proteomic features of subcellular fractions from rat hepatocytes and intensity of enzymatic and non-enzymatic free radical oxidation depending on the type of dietary fat during adaptation of animals to modified nutrition. Our results illustrate the formation of specific nutriproteomes in the microsomal and cytosolic fractions of rat hepatocytes (measurement of the macro-component and micro-component composition of diet).
ISSN:0007-4888
1573-8221
DOI:10.1007/s10517-013-1941-7