Are penicillins still relevant for empirical treatment in contemporary pediatric therapeutics?

Ampicillin and amoxicillin had higher in-vitro activity against Gram-positive agents, 18.3% and 58.7%, respectively, than penicillin G. Of the 1054 Gram-positive bacteria tested against amoxicillin-clavulanate (co-amoxiclav), 779 (73.9%) were sensitive. The low sensitivity to penicillin G may not be...

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Bibliographic Details
Published in:Annals of African medicine 2013-01, Vol.12 (1), p.59-60
Main Authors: Onalo, Richard, Adeleke, I, Onalo, Victoria
Format: Article
Language:English
Subjects:
Anti-Bacterial Agents - therapeutic use
Bacterial infections
Bacterial Infections - diagnosis
Bacterial Infections - drug therapy
Child, Preschool
Children
Diseases
Dosage and administration
Drug resistance in microorganisms
Gram-Negative Bacteria - drug effects
Gram-Negative Bacteria - isolation & purification
Gram-Positive Bacteria - drug effects
Gram-Positive Bacteria - isolation & purification
Hospitals, Teaching
Humans
Infections
Microbial Sensitivity Tests
Microbiology
Penicillin
Penicillins - therapeutic use
Pharmaceutical industry
Retrospective Studies
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Summary:Ampicillin and amoxicillin had higher in-vitro activity against Gram-positive agents, 18.3% and 58.7%, respectively, than penicillin G. Of the 1054 Gram-positive bacteria tested against amoxicillin-clavulanate (co-amoxiclav), 779 (73.9%) were sensitive. The low sensitivity to penicillin G may not be unconnected with its narrow bacteria coverage and its inability to resist β-lactamase. [...]there will be no justification for employing penicillin G in empirical treatment of suspected bacterial infections.
ISSN:1596-3519
0975-5764
DOI:10.4103/1596-3519.108259