The Role of Pregnancy-Specific Glycoprotein 1a (PSG1a) in Regulating the Innate and Adaptive Immune Response

Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the pregnant from the non‐p...

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Bibliographic Details
Published in:American journal of reproductive immunology (1989) 2013-04, Vol.69 (4), p.383-394
Main Authors: Martinez, Fernando F., Cervi, Laura, Knubel, Carolina P., Panzetta-Dutari, Graciela M., Motran, Claudia C.
Format: Article
Language:English
Subjects:
Adaptive Immunity
Animals
Antigen-Presenting Cells - immunology
CD4-Positive T-Lymphocytes - immunology
Dendritic cells
Female
Fetus - immunology
Humans
Immune system
Immunity, Innate
Lymphocyte Activation
macrophages
Macrophages - immunology
Macrophages - metabolism
Medical research
Placenta - immunology
Placenta - metabolism
Pregnancy
Pregnancy-Specific beta 1-Glycoproteins - metabolism
T cell receptors
Th1/Th2 cells
Th17 cells
Tolerance
Treg cells
Trophoblasts - immunology
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Summary:Among several explanations for the acceptance of the fetus, the one that suggests that the maternal immune system is suppressed or modified has been the subject of many studies. Thus, it has been proposed that the cells of innate immune system might be able to distinguish the pregnant from the non‐pregnant state producing a signal, the so‐called signal P. We have previously proposed that pregnancy‐specific glycoprotein 1a (PSG1a), a representative member of the main glycoprotein family secreted by placental trophoblast, may modulate the activation of antigen‐presenting cells promoting the T‐cell shift of the maternal cell immunity toward a less harmful phenotype. In this review, we summarize current knowledge concerning the contribution of pregnancy‐specific glycoprotein 1a (PSG1a) to modulate the maternal innate and adaptive immune response in order to assure a successful pregnancy.
ISSN:1046-7408
1600-0897
DOI:10.1111/aji.12089