Changes in expression of growth-associated protein-43 in trigeminal ganglion neurons and of the jaw opening reflex following inferior alveolar nerve transection in rats

• Published in: European journal of oral sciences 2013-04, Vol.121 (2), p.86-91
• Main Authors: Teramoto, Kohei, Tsuboi, Yoshiyuki, Shinoda, Masamichi, Hitomi, Suzuro, Abe, Kimiko, Kaji, Kaori, Tamagawa, Takaaki, Suzuki, Azumi, Noma, Noboru, Kobayashi, Masayuki, Komiyama, Osamu, Urata, Kentaro, Iwata, Koichi
• Format: Article
• Language: English
• Subjects: Analysis of Variance; Animals; Dentistry; GAP-43 Protein - metabolism; growth-associated protein-43; Immunohistochemistry; inferior alveolar nerve transection; jaw opening reflex; Nerve Regeneration - physiology; Neurons, Afferent - metabolism; Rats; Rats, Sprague-Dawley; Recovery of Function - physiology; Reflex, Abnormal - physiology; trigeminal ganglion; Trigeminal Ganglion - metabolism; Trigeminal Nerve Injuries - metabolism
• ISSN: 0909-8836; 1600-0722
• DOI: 10.1111/eos.12021

The aim of the present study was to clarify an involvement of growth‐associated protein‐43 (GAP‐43) in the regeneration of primary afferent trigeminal ganglion (TG) neurons following inferior alveolar nerve transection (IANX). A larger number of GAP‐43 immunoreactive (GAP‐43 IR) TG neurons was observed in rats 3 d after IANX compared with sham rats. Growth‐associated protein‐43 IR TG neurons were also detected for 30 d after IANX, and the number of GAP‐43 IR TG neurons was significantly higher in the IANX model until day 30. The relative number of large (>600 μm2) GAP‐43 IR TG neurons was significantly lower, whereas the relative number of small (