Relationship between status of plasma atrial natriuretic peptide and heart rate variability in human subjects

A relationship may exist between plasma atrial natriuretic peptide (P-ANP) and heart rate variability (HRV), which reflects the activity of the autonomic nervous system. We performed a survey in human subjects to examine the relationship between P-ANP and HRV parameters. Three ethnic groups (Han, Uy...

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Bibliographic Details
Published in:Heart and vessels 2013-03, Vol.28 (2), p.208-214
Main Authors: Kasamaki, Yuji, Izumi, Yoichi, Ozawa, Yukio, Ohta, Masakatsu, Tano, Ayako, Watanabe, Ichiro, Hirayama, Atsushi, Nakayama, Tomohiro, Kawamura, Hiroshi, Himit, Dilxat, Mahemuti, Maisumu, Sezai, Akira
Format: Article
Language:English
Subjects:
Aged
Asian Continental Ancestry Group
Atrial Natriuretic Factor - blood
Autonomic Nervous System - physiology
Biomarkers - blood
Biomedical Engineering and Bioengineering
Blood Pressure Monitoring, Ambulatory
Cardiac Surgery
Cardiology
China - epidemiology
Circadian Rhythm
Electrocardiography, Ambulatory
Female
Heart - innervation
Heart Rate
Humans
Linear Models
Male
Medicine
Medicine & Public Health
Multivariate Analysis
Nervous system
Original Article
Peptides
Time Factors
Vascular Surgery
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Summary:A relationship may exist between plasma atrial natriuretic peptide (P-ANP) and heart rate variability (HRV), which reflects the activity of the autonomic nervous system. We performed a survey in human subjects to examine the relationship between P-ANP and HRV parameters. Three ethnic groups (Han, Uygur, and Kazakh) provided blood and urine samples and underwent 24-h ambulatory blood pressure monitoring and 24-h ECG recording (24-h Holter ECG). There was a positive correlation between P-ANP and HF, as well as a negative correlation between P-ANP and the LF/HF ratio, in all subjects from the 3 ethnic groups. There was no association of BP with any of the blood, urinary, and HRV parameters. Our results suggested the possibility of a relationship between P-ANP and HRV, which reflects autonomic activity. These findings are consistent with the previous report of a close relationship between ANP and cardiac parasympathetic and/or sympathetic activity.
ISSN:0910-8327
1615-2573
DOI:10.1007/s00380-012-0237-6