Relationship between status of plasma atrial natriuretic peptide and heart rate variability in human subjects

• Published in: Heart and vessels 2013-03, Vol.28 (2), p.208-214
• Main Authors: Kasamaki, Yuji, Izumi, Yoichi, Ozawa, Yukio, Ohta, Masakatsu, Tano, Ayako, Watanabe, Ichiro, Hirayama, Atsushi, Nakayama, Tomohiro, Kawamura, Hiroshi, Himit, Dilxat, Mahemuti, Maisumu, Sezai, Akira
• Format: Article
• Language: English
• Subjects: Aged; Asian Continental Ancestry Group; Atrial Natriuretic Factor - blood; Autonomic Nervous System - physiology; Biomarkers - blood; Biomedical Engineering and Bioengineering; Blood Pressure Monitoring, Ambulatory; Cardiac Surgery; Cardiology; China - epidemiology; Circadian Rhythm; Electrocardiography, Ambulatory; Female; Heart - innervation; Heart Rate; Humans; Linear Models; Male; Medicine; Medicine & Public Health; Multivariate Analysis; Nervous system; Original Article; Peptides; Time Factors; Vascular Surgery
• ISSN: 0910-8327; 1615-2573
• DOI: 10.1007/s00380-012-0237-6

A relationship may exist between plasma atrial natriuretic peptide (P-ANP) and heart rate variability (HRV), which reflects the activity of the autonomic nervous system. We performed a survey in human subjects to examine the relationship between P-ANP and HRV parameters. Three ethnic groups (Han, Uygur, and Kazakh) provided blood and urine samples and underwent 24-h ambulatory blood pressure monitoring and 24-h ECG recording (24-h Holter ECG). There was a positive correlation between P-ANP and HF, as well as a negative correlation between P-ANP and the LF/HF ratio, in all subjects from the 3 ethnic groups. There was no association of BP with any of the blood, urinary, and HRV parameters. Our results suggested the possibility of a relationship between P-ANP and HRV, which reflects autonomic activity. These findings are consistent with the previous report of a close relationship between ANP and cardiac parasympathetic and/or sympathetic activity.